Potential roles of N6-methyladenosine (m6A) in immune cells
Abstract N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-06-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-02918-y |
| _version_ | 1818440919215505408 |
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| author | Chang Liu Zhe Yang Rong Li Yanju Wu Ming Chi Shuting Gao Xun Sun Xin Meng Biao Wang |
| author_facet | Chang Liu Zhe Yang Rong Li Yanju Wu Ming Chi Shuting Gao Xun Sun Xin Meng Biao Wang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | Abstract N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various diseases. The immune system mostly involves different types of immune cells to provide the first line of defense against infections. The immunoregulatory network that orchestrate the immune responses to new pathogens plays a pivotal role in the development of the disease. And m6A modification has been demonstrated to be a major post-transcriptional regulator of immune responses in cells. In this review, we summarize the participants involved in m6A regulation and try to reveal how m6A modification affects the immune responses via changing the immunoregulatory networks. |
| first_indexed | 2024-12-14T18:20:00Z |
| format | Article |
| id | doaj.art-e22efb20ddd4435791425a378b4f9fca |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-14T18:20:00Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-e22efb20ddd4435791425a378b4f9fca2022-12-21T22:52:06ZengBMCJournal of Translational Medicine1479-58762021-06-0119111310.1186/s12967-021-02918-yPotential roles of N6-methyladenosine (m6A) in immune cellsChang Liu0Zhe Yang1Rong Li2Yanju Wu3Ming Chi4Shuting Gao5Xun Sun6Xin Meng7Biao Wang8Department of Radiation Oncology, The First Affiliated Hospital of China Medical UniversityCollege of Life Science, Liaoning UniversityCollege of Life Science, Liaoning UniversityDepartment of Biochemistry and Molecular Biology, School of Life Sciences, China Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Life Sciences, China Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Life Sciences, China Medical UniversityDepartment of Immunology, College of Basic Medical Sciences of China Medical University,Department of Biochemistry and Molecular Biology, School of Life Sciences, China Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Life Sciences, China Medical UniversityAbstract N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various diseases. The immune system mostly involves different types of immune cells to provide the first line of defense against infections. The immunoregulatory network that orchestrate the immune responses to new pathogens plays a pivotal role in the development of the disease. And m6A modification has been demonstrated to be a major post-transcriptional regulator of immune responses in cells. In this review, we summarize the participants involved in m6A regulation and try to reveal how m6A modification affects the immune responses via changing the immunoregulatory networks.https://doi.org/10.1186/s12967-021-02918-yN6-methyladenosineImmune cellsRNAs |
| spellingShingle | Chang Liu Zhe Yang Rong Li Yanju Wu Ming Chi Shuting Gao Xun Sun Xin Meng Biao Wang Potential roles of N6-methyladenosine (m6A) in immune cells Journal of Translational Medicine N6-methyladenosine Immune cells RNAs |
| title | Potential roles of N6-methyladenosine (m6A) in immune cells |
| title_full | Potential roles of N6-methyladenosine (m6A) in immune cells |
| title_fullStr | Potential roles of N6-methyladenosine (m6A) in immune cells |
| title_full_unstemmed | Potential roles of N6-methyladenosine (m6A) in immune cells |
| title_short | Potential roles of N6-methyladenosine (m6A) in immune cells |
| title_sort | potential roles of n6 methyladenosine m6a in immune cells |
| topic | N6-methyladenosine Immune cells RNAs |
| url | https://doi.org/10.1186/s12967-021-02918-y |
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