Regional variances depict a unique glial-specific inflammatory response following closed-head injury
Mild traumatic brain injuries (mTBI) constitute a significant health concern with clinical symptoms ranging from headaches to cognitive deficits. Despite the myriad of symptoms commonly reported following this injury, there is still a lack of knowledge on the various pathophysiological changes that...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1076851/full |
| _version_ | 1828005643944984576 |
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| author | Michelle R. White Pamela J. VandeVord Pamela J. VandeVord |
| author_facet | Michelle R. White Pamela J. VandeVord Pamela J. VandeVord |
| author_sort | Michelle R. White |
| collection | DOAJ |
| description | Mild traumatic brain injuries (mTBI) constitute a significant health concern with clinical symptoms ranging from headaches to cognitive deficits. Despite the myriad of symptoms commonly reported following this injury, there is still a lack of knowledge on the various pathophysiological changes that occur. Preclinical studies are at the forefront of discovery delineating the changes that occur within this heterogeneous injury, with the emergence of translational models such as closed-head impact models allowing for further exploration of this injury mechanism. In the current study, male rats were subjected to a closed-head controlled cortical impact (cCCI), producing a concussion (mTBI). The pathological effects of this injury were then evaluated using immunoflourescence seven days following. The results exhibited a unique glial-specific inflammatory response, with both the ipsilateral and contralateral sides of the cortex and hippocampus showing pathological changes following impact. Overall these findings are consistent with glial changes reported following concussions and may contribute to subsequent symptoms. |
| first_indexed | 2024-04-10T07:34:48Z |
| format | Article |
| id | doaj.art-e22fea65e62a4ca9832bcd73ca863611 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T07:34:48Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-e22fea65e62a4ca9832bcd73ca8636112023-02-23T13:14:33ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-02-011710.3389/fncel.2023.10768511076851Regional variances depict a unique glial-specific inflammatory response following closed-head injuryMichelle R. White0Pamela J. VandeVord1Pamela J. VandeVord2Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United StatesDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United StatesSalem VA Medical Center, Salem, VA, United StatesMild traumatic brain injuries (mTBI) constitute a significant health concern with clinical symptoms ranging from headaches to cognitive deficits. Despite the myriad of symptoms commonly reported following this injury, there is still a lack of knowledge on the various pathophysiological changes that occur. Preclinical studies are at the forefront of discovery delineating the changes that occur within this heterogeneous injury, with the emergence of translational models such as closed-head impact models allowing for further exploration of this injury mechanism. In the current study, male rats were subjected to a closed-head controlled cortical impact (cCCI), producing a concussion (mTBI). The pathological effects of this injury were then evaluated using immunoflourescence seven days following. The results exhibited a unique glial-specific inflammatory response, with both the ipsilateral and contralateral sides of the cortex and hippocampus showing pathological changes following impact. Overall these findings are consistent with glial changes reported following concussions and may contribute to subsequent symptoms.https://www.frontiersin.org/articles/10.3389/fncel.2023.1076851/fullastrocytesaquaporin (AQP) 4microgliaconcussionclosed-head controlled cortical impactclosed-head injury |
| spellingShingle | Michelle R. White Pamela J. VandeVord Pamela J. VandeVord Regional variances depict a unique glial-specific inflammatory response following closed-head injury Frontiers in Cellular Neuroscience astrocytes aquaporin (AQP) 4 microglia concussion closed-head controlled cortical impact closed-head injury |
| title | Regional variances depict a unique glial-specific inflammatory response following closed-head injury |
| title_full | Regional variances depict a unique glial-specific inflammatory response following closed-head injury |
| title_fullStr | Regional variances depict a unique glial-specific inflammatory response following closed-head injury |
| title_full_unstemmed | Regional variances depict a unique glial-specific inflammatory response following closed-head injury |
| title_short | Regional variances depict a unique glial-specific inflammatory response following closed-head injury |
| title_sort | regional variances depict a unique glial specific inflammatory response following closed head injury |
| topic | astrocytes aquaporin (AQP) 4 microglia concussion closed-head controlled cortical impact closed-head injury |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1076851/full |
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