Molecular Mechanisms of Mouse Skin Tumor Promotion

Molecular Mechanisms of Mouse Skin Tumor Promotion

Multiple molecular mechanisms are involved in the promotion of skin carcinogenesis. Induction of sustained proliferation and epidermal hyperplasia by direct activation of mitotic signaling pathways or indirectly in response to chronic wounding and/or inflammation, or due to a block in terminal diffe...

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Bibliographic Details
Main Authors:	Joyce E. Rundhaug, Susan M. Fischer
Format:	Article
Language:	English
Published:	MDPI AG 2010-04-01
Series:	Cancers
Subjects:	skin carcinogenesis tumor promoters 12-O-tetradecanoylphorbol 13-acetate (TPA) protein kinase C (PKC) epidermal growth factor receptor (EGFR) transforming growth factor-β (TGFβ) tumor necrosis factor-α (TNFα) interleukins cyclooxygenase-2 (COX-2) ornithine decarboxylase (ODC)
Online Access:	http://www.mdpi.com/2072-6694/2/2/436/

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