SMAD4 inhibits glycolysis in ovarian cancer through PI3K/AKT/HK2 signaling pathway by activating ARHGAP10

SMAD4 inhibits glycolysis in ovarian cancer through PI3K/AKT/HK2 signaling pathway by activating ARHGAP10

Abstract Background ARHGAP10 is a tumor‐suppressor gene related to ovarian cancer (OC) progression; however, its specific mechanism is unclear. Aims To investigate the effect of ARHGAP10 on OC cell migration, invasion, and glycolysis. Methods and Results Quantitative real‐time PCR (qRT‐PCR) quantifi...

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Bibliographic Details
Main Authors: Kui Wu, Wei Gong, Huanmei Sun, Wenjiao Li, Li Chen, Yingchun Duan, Jianlong Zhu, Hu Zhang, Huihui Ke
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Cancer Reports
Subjects:
ARHGAP10
glycolysis
hexokinase‐II
lactate
ovarian cancer
Online Access:https://doi.org/10.1002/cnr2.1976

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