Investigating Pathways of Ventilation Induced Brain Injury on Cerebral White Matter Inflammation and Injury After 24 h in Preterm Lambs

Investigating Pathways of Ventilation Induced Brain Injury on Cerebral White Matter Inflammation and Injury After 24 h in Preterm Lambs

Initiation of respiratory support in the delivery room increases the risk and severity of brain injury in preterm neonates through two major pathways: an inflammatory pathway and a haemodynamic pathway. The relative contribution of each pathway on preterm brain injury is not known. We aimed to asses...

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Bibliographic Details
Main Authors: Kyra YY Chan, Nhi T. Tran, Paris C. Papagianis, Valerie A. Zahra, Ilias Nitsos, Alison M. Moxham, Domenic A. LaRosa, Courtney McDonald, Suzanne L. Miller, Robert Galinsky, Dhafer M. Alahmari, Vanesa Stojanovska, Graeme R. Polglase
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Physiology
Subjects:
ventilation-induced brain injury
mechanical ventilation
preterm
white matter injury
mechanisms
cerebral inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.904144/full

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