PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway

PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway

Gluconeogenesis, generates glucose from small carbohydrate substrates, and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting enzyme in gluconeogenesis, initiates the gluconeogenesis proces...

Full description

Bibliographic Details
Main Authors:	Lin Tuo, Jin Xiang, Xuanming Pan, Qingzhu Gao, Guiji Zhang, Yi Yang, Li Liang, Jie Xia, Kai Wang, Ni Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-12-01
Series:	Frontiers in Oncology
Subjects:	phosphoenolpyruvate carboxylase kinase 1 thioredoxin reductase 1 hepatocellular carcinoma reactive oxygen species nuclear factor erythroid 2-related factor 2
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2018.00611/full

Similar Items

Expression Profiles of Phosphoenolpyruvate Carboxylase and Phosphoenolpyruvate Carboxylase Kinase Genes in Phalaenopsis, Implications for Regulating the Performance of Crassulacean Acid Metabolism
by: Chia-Yun Ping, et al.
Published: (2018-10-01)

Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells
by: Kaori Yama, et al.
Published: (2015-04-01)

Phosphoenolpyruvate carboxylase (PEPC) is essential for the glycolytic pathway and parasite proliferation in Babesia gibsoni
by: Dong-Fang Li, et al.
Published: (2024-12-01)

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions
by: Jannick Kappelmann, et al.
Published: (2021-01-01)

Txnrd1 as a prognosticator for recurrence, metastasis and response to neoadjuvant chemotherapy and radiotherapy in breast cancer patients
by: Raghavendra S. Patwardhan, et al.
Published: (2024-03-01)

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis
by: Giovanni Tossetta, et al.
Published: (2024-10-01)

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update
by: Christina Thanas, et al.
Published: (2020-11-01)

Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families
by: Marwa Al Busaidi, et al.
Published: (2023-11-01)

Effects of Citric Acid and Humic-like Substances on Yield, Enzyme Activities, and Expression of Genes Involved in Iron Uptake in Tomato Plants
by: Fabián Pérez-Labrada, et al.
Published: (2023-05-01)

Overexpression of PCK1 Gene Antagonizes Hepatocellular Carcinoma Through the Activation of Gluconeogenesis and Suppression of Glycolysis Pathways
by: Yufu Tang, et al.
Published: (2018-05-01)

Procyanidin A1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through regulating Keap1/Nrf2 pathway
by: Fangfang Yan, et al.
Published: (2024-05-01)

Increased ethylene production by overexpressing phosphoenolpyruvate carboxylase in the cyanobacterium Synechocystis PCC 6803
by: Claudia Durall, et al.
Published: (2020-01-01)

The diagnostic potential role of thioredoxin reductase and TXNRD1 in early lung adenocarcinoma: A cohort study
by: Guanyu Jiang, et al.
Published: (2024-06-01)

The antisense expression of AhPEPC1 increases seed oil production in peanuts (Arachis hypogaea L.)
by: L. Pan, et al.
Published: (2016-12-01)

NRF2 and Thioredoxin Reductase 1 as Modulators of Interactions between Zinc and Selenium
by: Alina Löser, et al.
Published: (2024-10-01)

Utilization of urea by leaves of bromeliad Vriesea gigantea under water deficit: much more than a nitrogen source
by: A. Matiz, et al.
Published: (2017-12-01)

Maresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway
by: Yufei Li, et al.
Published: (2023-09-01)

The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment
by: Romina Bertinat, et al.
Published: (2025-04-01)

Nitrogen metabolism-related enzymes in Mesembryanthemum crystallinum after Botrytis cinerea infection
by: E. Gajewska, et al.
Published: (2018-09-01)

Serum anti-PCK1 antibody levels are a prognostic factor for patients with diabetes mellitus
by: Toshiki Namiki, et al.
Published: (2023-10-01)

Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune Diseases
by: Dionysios V. Chartoumpekis, et al.
Published: (2020-11-01)

Ischemic Postconditioning-Mediated DJ-1 Activation Mitigate Intestinal Mucosa Injury Induced by Myocardial Ischemia Reperfusion in Rats Through Keap1/Nrf2 Pathway
by: Rong Chen, et al.
Published: (2021-04-01)

Nrf2 regulates the activation of THP-1 cells induced by chloral hydrate
by: Jinfeng Zhao, et al.
Published: (2023-05-01)

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
by: Yoshinobu Ichimura, et al.
Published: (2018-06-01)

Beta-1-Adrenergic Receptors Mediate Nrf2-HO-1-HMGB1 Axis Regulation to Attenuate Hypoxia/Reoxygenation-Induced Cardiomyocytes Injury in Vitro
by: Jichun Wang, et al.
Published: (2015-01-01)

Conservation and Divergence of <i>PEPC</i> Gene Family in Different Ploidy Bamboos
by: Wenlong Cheng, et al.
Published: (2024-08-01)

Effects of salt and alkali stress on growth, accumulation of oxalic acid, and activity of oxalic acid-metabolizing enzymes in Kochia sieversiana
by: Y. Ma, et al.
Published: (2016-12-01)

Astragaloside IV prevents enterovirus 71-induced pyroptosis through the TCF12-TXNIP-Keap1/Nrf2 axis
by: JinFang Hao, et al.
Published: (2024-07-01)

PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth
by: Xiangyan Zhang, et al.
Published: (2023-04-01)

Comparative transcriptome analysis reveals that PCK1 is a potential gene affecting IMF deposition in buffalo
by: Jieping Huang, et al.
Published: (2020-10-01)

Translocator protein activates autophagy in diabetic neuropathic pain rats via regulation of the Keap1/Nrf2/HO-1 signaling
by: GAO Nan, et al.
Published: (2023-08-01)

Targeting Nrf2 signaling in dry eye
by: Yu-Nuo Zhang, et al.
Published: (2024-10-01)

Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption
by: Pamela Lopert, et al.
Published: (2014-01-01)

Differences in Physiological Responses of Two Oat (<i>Avena nuda</i> L.) Lines to Sodic-Alkalinity in the Vegetative Stage
by: Liyun Liu, et al.
Published: (2020-09-01)

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma
by: Catrin S. Rutland, et al.
Published: (2021-08-01)

ZmOrphan94 Transcription Factor Downregulates ZmPEPC1 Gene Expression in Maize Bundle Sheath Cells
by: Alicja M. Górska, et al.
Published: (2021-04-01)

Effects of High Night Temperature on Crassulacean Acid Metabolism (CAM) Photosynthesis of Kalanchoë pinnata and Ananas comosus
by: Qin Lin, et al.
Published: (2006-01-01)

Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia
by: Rachel K. Toth, et al.
Published: (2017-04-01)

Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives
by: Zilong Song, et al.
Published: (2023-08-01)

DJ‐1 plays a neuroprotective role in SH‐SY5Y cells by modulating Nrf2 signaling in response to lidocaine‐mediated oxidative stress and apoptosis
by: Ying Xue, et al.
Published: (2020-08-01)