Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis
The formation of functional eggs (oocyte) in ovarian follicles is arguably one of the most important events in early mammalian development since the oocytes provide the bulk genetic and cytoplasmic materials for successful reproduction. While past studies have identified many genes that are critical...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1038107/full |
| _version_ | 1811316191437783040 |
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| author | Arikta Biswas Boon Heng Ng Vinod S/O Prabhakaran Chii Jou Chan Chii Jou Chan |
| author_facet | Arikta Biswas Boon Heng Ng Vinod S/O Prabhakaran Chii Jou Chan Chii Jou Chan |
| author_sort | Arikta Biswas |
| collection | DOAJ |
| description | The formation of functional eggs (oocyte) in ovarian follicles is arguably one of the most important events in early mammalian development since the oocytes provide the bulk genetic and cytoplasmic materials for successful reproduction. While past studies have identified many genes that are critical to normal ovarian development and function, recent studies have highlighted the role of mechanical force in shaping folliculogenesis. In this review, we discuss the underlying mechanobiological principles and the force-generating cellular structures and extracellular matrix that control the various stages of follicle development. We also highlight emerging techniques that allow for the quantification of mechanical interactions and follicular dynamics during development, and propose new directions for future studies in the field. We hope this review will provide a timely and useful framework for future understanding of mechano-signalling pathways in reproductive biology and diseases. |
| first_indexed | 2024-04-13T11:44:32Z |
| format | Article |
| id | doaj.art-e2333b7a591a47bbabe7fc499ba75321 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T11:44:32Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e2333b7a591a47bbabe7fc499ba753212022-12-22T02:48:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.10381071038107Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesisArikta Biswas0Boon Heng Ng1Vinod S/O Prabhakaran2Chii Jou Chan3Chii Jou Chan4Mechanobiology Institute, National University of Singapore, Singapore, SingaporeMechanobiology Institute, National University of Singapore, Singapore, SingaporeMechanobiology Institute, National University of Singapore, Singapore, SingaporeMechanobiology Institute, National University of Singapore, Singapore, SingaporeDepartment of Biological Sciences, National University of Singapore, Singapore, SingaporeThe formation of functional eggs (oocyte) in ovarian follicles is arguably one of the most important events in early mammalian development since the oocytes provide the bulk genetic and cytoplasmic materials for successful reproduction. While past studies have identified many genes that are critical to normal ovarian development and function, recent studies have highlighted the role of mechanical force in shaping folliculogenesis. In this review, we discuss the underlying mechanobiological principles and the force-generating cellular structures and extracellular matrix that control the various stages of follicle development. We also highlight emerging techniques that allow for the quantification of mechanical interactions and follicular dynamics during development, and propose new directions for future studies in the field. We hope this review will provide a timely and useful framework for future understanding of mechano-signalling pathways in reproductive biology and diseases.https://www.frontiersin.org/articles/10.3389/fcell.2022.1038107/fullfolliculogenesismechanobiologyoocytemechanotransductionmammalian reproductiontheca cell |
| spellingShingle | Arikta Biswas Boon Heng Ng Vinod S/O Prabhakaran Chii Jou Chan Chii Jou Chan Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis Frontiers in Cell and Developmental Biology folliculogenesis mechanobiology oocyte mechanotransduction mammalian reproduction theca cell |
| title | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis |
| title_full | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis |
| title_fullStr | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis |
| title_full_unstemmed | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis |
| title_short | Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis |
| title_sort | squeezing the eggs to grow the mechanobiology of mammalian folliculogenesis |
| topic | folliculogenesis mechanobiology oocyte mechanotransduction mammalian reproduction theca cell |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1038107/full |
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