Lipase Catalyzed Synthesis of Enantiopure Precursors and Derivatives for β-Blockers Practolol, Pindolol and Carteolol

Lipase Catalyzed Synthesis of Enantiopure Precursors and Derivatives for β-Blockers Practolol, Pindolol and Carteolol

Sustainable methods for producing enantiopure drugs have been developed. Chlorohydrins as building blocks for several β-blockers have been synthesized in high enantiomeric purity by chemo-enzymatic methods. The yield of the chlorohydrins increased by the use of catalytic amount of base. The reason f...

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Bibliographic Details
Main Authors: Morten Andre Gundersen, Guro Buaas Austli, Sigrid Sløgedal Løvland, Mari Bergan Hansen, Mari Rødseth, Elisabeth Egholm Jacobsen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Catalysts
Subjects:
(<i>S</i>)-practolol
paracetamol
(<i>S</i>)-pindolol
(<i>S</i>)-carteolol
<i>Candida antarctica</i> Lipase B
chiral chromatography
Online Access:https://www.mdpi.com/2073-4344/11/4/503

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