Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients
<i>Background and Objectives:</i> Determining the clinical course of multiple sclerosis (MS) and prediction of long-term disability can be a big challenge. To determine early clinical features of MS, their influence on long-term disability progression, and time to transition from relapsi...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/6/232 |
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| author | Łukasz Rzepiński Monika Zawadka-Kunikowska Zdzisław Maciejek Julia L. Newton Paweł Zalewski |
| author_facet | Łukasz Rzepiński Monika Zawadka-Kunikowska Zdzisław Maciejek Julia L. Newton Paweł Zalewski |
| author_sort | Łukasz Rzepiński |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Determining the clinical course of multiple sclerosis (MS) and prediction of long-term disability can be a big challenge. To determine early clinical features of MS, their influence on long-term disability progression, and time to transition from relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS), a cohort of Polish patients was studied. <i>Materials and Methods:</i> We retrospectively evaluated 375 Polish MS patients based on data from available medical records. We assessed early clinical MS features and the relationship between demographics and time from disease onset to attainment of 4 and 6 points on the Expanded Disability Status Scale (EDSS), as well as time to conversion from RRMS to SPMS. <i>Results:</i> The differences between initial MS variants were significantly associated with gender, age at disease onset, number and type of the first symptoms, and rate of the disability accrual. Mean times from disease onset to attainment of EDSS 4 and 6 were significantly influenced by the disease variant, age at onset, gender, degree of recovery from the initial symptoms, and first inter-bouts interval. The mean time to secondary progression was significantly influenced by the number and type of the first symptoms of RRMS. <i>Conclusions:</i> Early clinical features of MS are important in determining the disease variant, the time to transition from RRMS to SPMS, as well as predicting the disability accumulation of patients. Despite the small differences regarding the first MS symptoms, the disability outcomes in the cohort of Polish patients are similar to other regions of the world. |
| first_indexed | 2024-03-12T06:05:12Z |
| format | Article |
| id | doaj.art-e23461178dd84ea6bd8ff04b1fa158da |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:05:12Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e23461178dd84ea6bd8ff04b1fa158da2023-09-03T03:45:07ZengMDPI AGMedicina1010-660X2019-05-0155623210.3390/medicina55060232medicina55060232Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis PatientsŁukasz Rzepiński0Monika Zawadka-Kunikowska1Zdzisław Maciejek2Julia L. Newton3Paweł Zalewski4Department of Neurology, 10th Military Research Hospital and Polyclinic, 85-681 Bydgoszcz, PolandDepartment of Hygiene, Epidemiology and Ergonomy, Nicolaus Copernicus University, Torun, 85-094 Bydgoszcz, PolandDepartment of Neurology, 10th Military Research Hospital and Polyclinic, 85-681 Bydgoszcz, PolandInstitute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle Upon Tyne NE2 4HH, UKDepartment of Hygiene, Epidemiology and Ergonomy, Nicolaus Copernicus University, Torun, 85-094 Bydgoszcz, Poland<i>Background and Objectives:</i> Determining the clinical course of multiple sclerosis (MS) and prediction of long-term disability can be a big challenge. To determine early clinical features of MS, their influence on long-term disability progression, and time to transition from relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS), a cohort of Polish patients was studied. <i>Materials and Methods:</i> We retrospectively evaluated 375 Polish MS patients based on data from available medical records. We assessed early clinical MS features and the relationship between demographics and time from disease onset to attainment of 4 and 6 points on the Expanded Disability Status Scale (EDSS), as well as time to conversion from RRMS to SPMS. <i>Results:</i> The differences between initial MS variants were significantly associated with gender, age at disease onset, number and type of the first symptoms, and rate of the disability accrual. Mean times from disease onset to attainment of EDSS 4 and 6 were significantly influenced by the disease variant, age at onset, gender, degree of recovery from the initial symptoms, and first inter-bouts interval. The mean time to secondary progression was significantly influenced by the number and type of the first symptoms of RRMS. <i>Conclusions:</i> Early clinical features of MS are important in determining the disease variant, the time to transition from RRMS to SPMS, as well as predicting the disability accumulation of patients. Despite the small differences regarding the first MS symptoms, the disability outcomes in the cohort of Polish patients are similar to other regions of the world.https://www.mdpi.com/1010-660X/55/6/232multiple sclerosisdisabilityconversionPoland |
| spellingShingle | Łukasz Rzepiński Monika Zawadka-Kunikowska Zdzisław Maciejek Julia L. Newton Paweł Zalewski Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients Medicina multiple sclerosis disability conversion Poland |
| title | Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients |
| title_full | Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients |
| title_fullStr | Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients |
| title_full_unstemmed | Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients |
| title_short | Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients |
| title_sort | early clinical features time to secondary progression and disability milestones in polish multiple sclerosis patients |
| topic | multiple sclerosis disability conversion Poland |
| url | https://www.mdpi.com/1010-660X/55/6/232 |
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