Role of fasting duration and weekday in incretin and glucose regulation
Fasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism. We investigated associations of fasting duration and weekday of examination with glucose, insulin, g...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2020-04-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/aop/ec-20-0009/ec-20-0009.xml |
| _version_ | 1818030617362694144 |
|---|---|
| author | Kim K B Clemmensen Jonas S Quist Dorte Vistisen Daniel R Witte Anna Jonsson Oluf Pedersen Torben Hansen Jens J Holst Torsten Lauritzen Marit E Jørgensen Signe Torekov Kristine Færch |
| author_facet | Kim K B Clemmensen Jonas S Quist Dorte Vistisen Daniel R Witte Anna Jonsson Oluf Pedersen Torben Hansen Jens J Holst Torsten Lauritzen Marit E Jørgensen Signe Torekov Kristine Færch |
| author_sort | Kim K B Clemmensen |
| collection | DOAJ |
| description | Fasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism. We investigated associations of fasting duration and weekday of examination with glucose, insulin, glucagon and incretin responses to an oral glucose tolerance test (OGTT). This cross-sectional study is based on data from the ADDITION-PRO study, where 2082 individuals attended a health examination including an OGTT. Linear regression analysis was applied to study the associations of overnight fasting duration and day of the week with glucose, insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) responses to an OGTT. We found that a 1 h longer fasting duration was associated with 1.7% (95% CI: 0.8,2.5) higher 2-h glucose levels, as well as a 3.0% (95% CI: 1.3,4.7) higher GIP and 2.3% (95% CI: 0.3,4.4) higher GLP-1 response. Fasting insulin levels were 20.6% (95% CI: 11.2,30.7) higher on Mondays compared to the other weekdays, with similar fasting glucose levels (1.7%, 95% CI: 0.0,3.4). In this study, longer overnight fasting duration was associated with a worsening of glucose tolerance and increased incretin response to oral glucose. We found higher fasting insulin levels on Mondays compared to the other days of the week, potentially indicating a worsened glucose regulation after the weekend. |
| first_indexed | 2024-12-10T05:38:26Z |
| format | Article |
| id | doaj.art-e235480fcdb24df28872c70ffada4f7d |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-10T05:38:26Z |
| publishDate | 2020-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-e235480fcdb24df28872c70ffada4f7d2022-12-22T02:00:21ZengBioscientificaEndocrine Connections2049-36142049-36142020-04-0194279288https://doi.org/10.1530/EC-20-0009Role of fasting duration and weekday in incretin and glucose regulationKim K B Clemmensen0Jonas S Quist1Dorte Vistisen2Daniel R Witte3Anna Jonsson4Oluf Pedersen5Torben Hansen6Jens J Holst7Torsten Lauritzen8Marit E Jørgensen9Signe Torekov10Kristine Færch11Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, DenmarkDepartment of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, DenmarkDepartment of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, DenmarkDepartment of Public Health, Aarhus University, Aarhus, Denmark; Danish Diabetes Academy, Odense, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkSection for General Practice, Department of Public Health, Aarhus University, Aarhus, DenmarkDepartment of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, DenmarkFasting duration has been associated with lower fasting blood glucose levels, but higher 2-h post-load levels, and research has indicated an adverse effe ct of ‘weekend behavior’ on human metabolism. We investigated associations of fasting duration and weekday of examination with glucose, insulin, glucagon and incretin responses to an oral glucose tolerance test (OGTT). This cross-sectional study is based on data from the ADDITION-PRO study, where 2082 individuals attended a health examination including an OGTT. Linear regression analysis was applied to study the associations of overnight fasting duration and day of the week with glucose, insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) responses to an OGTT. We found that a 1 h longer fasting duration was associated with 1.7% (95% CI: 0.8,2.5) higher 2-h glucose levels, as well as a 3.0% (95% CI: 1.3,4.7) higher GIP and 2.3% (95% CI: 0.3,4.4) higher GLP-1 response. Fasting insulin levels were 20.6% (95% CI: 11.2,30.7) higher on Mondays compared to the other weekdays, with similar fasting glucose levels (1.7%, 95% CI: 0.0,3.4). In this study, longer overnight fasting duration was associated with a worsening of glucose tolerance and increased incretin response to oral glucose. We found higher fasting insulin levels on Mondays compared to the other days of the week, potentially indicating a worsened glucose regulation after the weekend.https://ec.bioscientifica.com/view/journals/ec/aop/ec-20-0009/ec-20-0009.xmlfasting durationincretinoral glucose tolerance testweekdaymetabolism |
| spellingShingle | Kim K B Clemmensen Jonas S Quist Dorte Vistisen Daniel R Witte Anna Jonsson Oluf Pedersen Torben Hansen Jens J Holst Torsten Lauritzen Marit E Jørgensen Signe Torekov Kristine Færch Role of fasting duration and weekday in incretin and glucose regulation Endocrine Connections fasting duration incretin oral glucose tolerance test weekday metabolism |
| title | Role of fasting duration and weekday in incretin and glucose regulation |
| title_full | Role of fasting duration and weekday in incretin and glucose regulation |
| title_fullStr | Role of fasting duration and weekday in incretin and glucose regulation |
| title_full_unstemmed | Role of fasting duration and weekday in incretin and glucose regulation |
| title_short | Role of fasting duration and weekday in incretin and glucose regulation |
| title_sort | role of fasting duration and weekday in incretin and glucose regulation |
| topic | fasting duration incretin oral glucose tolerance test weekday metabolism |
| url | https://ec.bioscientifica.com/view/journals/ec/aop/ec-20-0009/ec-20-0009.xml |
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