Perthamide C inhibits eNOS and iNOS expression and has immunomodulating activity in vivo.

Perthamide C inhibits eNOS and iNOS expression and has immunomodulating activity in vivo.

Here we have characterized perthamide C, a cyclopeptide from a Solomon Lithistid sponge Theonella swinhoei, which displays an anti-inflammatory/immunomodulatory activity. The study has been performed using the carragenan-induced mouse paw edema that displays an early (0-6 h) and a late phase (24-96...

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Bibliographic Details
Main Authors: Mariarosaria Bucci, Anna Cantalupo, Valentina Vellecco, Elisabetta Panza, Maria Chiara Monti, Angela Zampella, Angela Ianaro, Giuseppe Cirino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3595234?pdf=render

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