Serum neopterin level in cases of pulmonary tuberculosis and pneumonia
Abstract Background Pulmonary tuberculosis (TB) sometimes has diagnostic difficulties and a lot of differential diagnosis such as pneumonia. The aim of this work was to assess the role of serum neopterin in differentiating between pulmonary TB and pneumonia and to estimate the effect of antitubercul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-06-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.4103/1687-8426.184360 |
| _version_ | 1828452917694169088 |
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| author | Wafaa S. El-Shimy Adel S. Bediwy Azza M. Hassan Lamiaa R. Ismail |
| author_facet | Wafaa S. El-Shimy Adel S. Bediwy Azza M. Hassan Lamiaa R. Ismail |
| author_sort | Wafaa S. El-Shimy |
| collection | DOAJ |
| description | Abstract Background Pulmonary tuberculosis (TB) sometimes has diagnostic difficulties and a lot of differential diagnosis such as pneumonia. The aim of this work was to assess the role of serum neopterin in differentiating between pulmonary TB and pneumonia and to estimate the effect of antituberculous drugs for 2 months on serum levels of neopterin in patients with pulmonary TB. Patients and methods We measured serum neopterin in patients with TB, pneumonia patients, and controls. Serum neopterin was measured again after 2 months of antituberculous therapy in patients with pulmonary TB. Results Serum neopterin was significantly higher in tuberculous patients than in pneumonia patients, with a sensitivity of 90% and a specificity of 80% at an optimal cut-off value of 20.5 nmol/l. It decreased significantly after 2 months of antituberculous therapy in tuberculous patients. Conclusion Serum neopterin levels significantly increase in pulmonary TB and correlate with the radiological extent of the disease. Combined anti-TB treatment decreases the levels of serum neopterin. Measurement of the serum neopterin levels may be useful in following up the drug response in pulmonary TB. Serum neopterin levels may also be helpful in discriminating pulmonary TB from pneumonia. |
| first_indexed | 2024-12-10T23:59:45Z |
| format | Article |
| id | doaj.art-e2369e6d395b4b4dae9949913136ef15 |
| institution | Directory Open Access Journal |
| issn | 1687-8426 2314-8551 |
| language | English |
| last_indexed | 2024-12-10T23:59:45Z |
| publishDate | 2016-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-e2369e6d395b4b4dae9949913136ef152022-12-22T01:28:30ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512016-06-0110214014610.4103/1687-8426.184360Serum neopterin level in cases of pulmonary tuberculosis and pneumoniaWafaa S. El-Shimy0Adel S. Bediwy1Azza M. Hassan2Lamiaa R. Ismail3Department of Chest, Faculty of Medicine, Tanta UniversityDepartment of Chest, Faculty of Medicine, Tanta UniversityDepartment of Microbiology and Immunology, Faculty of Medicine, Tanta UniversityAl-Mahalla Chest HospitalAbstract Background Pulmonary tuberculosis (TB) sometimes has diagnostic difficulties and a lot of differential diagnosis such as pneumonia. The aim of this work was to assess the role of serum neopterin in differentiating between pulmonary TB and pneumonia and to estimate the effect of antituberculous drugs for 2 months on serum levels of neopterin in patients with pulmonary TB. Patients and methods We measured serum neopterin in patients with TB, pneumonia patients, and controls. Serum neopterin was measured again after 2 months of antituberculous therapy in patients with pulmonary TB. Results Serum neopterin was significantly higher in tuberculous patients than in pneumonia patients, with a sensitivity of 90% and a specificity of 80% at an optimal cut-off value of 20.5 nmol/l. It decreased significantly after 2 months of antituberculous therapy in tuberculous patients. Conclusion Serum neopterin levels significantly increase in pulmonary TB and correlate with the radiological extent of the disease. Combined anti-TB treatment decreases the levels of serum neopterin. Measurement of the serum neopterin levels may be useful in following up the drug response in pulmonary TB. Serum neopterin levels may also be helpful in discriminating pulmonary TB from pneumonia.http://link.springer.com/article/10.4103/1687-8426.184360neopterinpneumoniapulmonary tuberculosis |
| spellingShingle | Wafaa S. El-Shimy Adel S. Bediwy Azza M. Hassan Lamiaa R. Ismail Serum neopterin level in cases of pulmonary tuberculosis and pneumonia The Egyptian Journal of Bronchology neopterin pneumonia pulmonary tuberculosis |
| title | Serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| title_full | Serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| title_fullStr | Serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| title_full_unstemmed | Serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| title_short | Serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| title_sort | serum neopterin level in cases of pulmonary tuberculosis and pneumonia |
| topic | neopterin pneumonia pulmonary tuberculosis |
| url | http://link.springer.com/article/10.4103/1687-8426.184360 |
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