Heme oxygenase-1 and carbon monoxide in pulmonary medicine
<p>Abstract</p> <p>Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-08-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/4/1/7 |
| _version_ | 1818857166101020672 |
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| author | Choi Augustine MK Ryter Stefan W Slebos Dirk-Jan |
| author_facet | Choi Augustine MK Ryter Stefan W Slebos Dirk-Jan |
| author_sort | Choi Augustine MK |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammation, and apoptosis. By virtue of anti-inflammatory effects, HO-1 limits tissue damage in response to proinflammatory stimuli and prevents allograft rejection after transplantation. The transcriptional upregulation of HO-1 responds to many agents, such as hypoxia, bacterial lipopolysaccharide, and reactive oxygen/nitrogen species. HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXα, ferrous iron, and carbon monoxide (CO). The mechanisms by which HO-1 provides protection most likely involve its enzymatic reaction products. Remarkably, administration of CO at low concentrations can substitute for HO-1 with respect to anti-inflammatory and anti-apoptotic effects, suggesting a role for CO as a key mediator of HO-1 function. Chronic, low-level, exogenous exposure to CO from cigarette smoking contributes to the importance of CO in pulmonary medicine. The implications of the HO-1/CO system in pulmonary diseases will be discussed in this review, with an emphasis on inflammatory states.</p> |
| first_indexed | 2024-12-19T08:36:04Z |
| format | Article |
| id | doaj.art-e238034452854f078d7bd5195460307c |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-19T08:36:04Z |
| publishDate | 2003-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-e238034452854f078d7bd5195460307c2022-12-21T20:29:03ZengBMCRespiratory Research1465-99212003-08-0141710.1186/1465-9921-4-7Heme oxygenase-1 and carbon monoxide in pulmonary medicineChoi Augustine MKRyter Stefan WSlebos Dirk-Jan<p>Abstract</p> <p>Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammation, and apoptosis. By virtue of anti-inflammatory effects, HO-1 limits tissue damage in response to proinflammatory stimuli and prevents allograft rejection after transplantation. The transcriptional upregulation of HO-1 responds to many agents, such as hypoxia, bacterial lipopolysaccharide, and reactive oxygen/nitrogen species. HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXα, ferrous iron, and carbon monoxide (CO). The mechanisms by which HO-1 provides protection most likely involve its enzymatic reaction products. Remarkably, administration of CO at low concentrations can substitute for HO-1 with respect to anti-inflammatory and anti-apoptotic effects, suggesting a role for CO as a key mediator of HO-1 function. Chronic, low-level, exogenous exposure to CO from cigarette smoking contributes to the importance of CO in pulmonary medicine. The implications of the HO-1/CO system in pulmonary diseases will be discussed in this review, with an emphasis on inflammatory states.</p>http://respiratory-research.com/content/4/1/7carbon monoxideheme oxygenase-1lung disease |
| spellingShingle | Choi Augustine MK Ryter Stefan W Slebos Dirk-Jan Heme oxygenase-1 and carbon monoxide in pulmonary medicine Respiratory Research carbon monoxide heme oxygenase-1 lung disease |
| title | Heme oxygenase-1 and carbon monoxide in pulmonary medicine |
| title_full | Heme oxygenase-1 and carbon monoxide in pulmonary medicine |
| title_fullStr | Heme oxygenase-1 and carbon monoxide in pulmonary medicine |
| title_full_unstemmed | Heme oxygenase-1 and carbon monoxide in pulmonary medicine |
| title_short | Heme oxygenase-1 and carbon monoxide in pulmonary medicine |
| title_sort | heme oxygenase 1 and carbon monoxide in pulmonary medicine |
| topic | carbon monoxide heme oxygenase-1 lung disease |
| url | http://respiratory-research.com/content/4/1/7 |
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