Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary
A carbapenem-resistant S. marcescens isolate was recovered from a patient with an inflammed pacemaker inplantation pocket from a Cardiac Surgery ward in a Hungarian University Hospital. Phenotypic tests and polymerase chain reaction (PCR) confirmed a very rare gene responsible for production of a ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020310756 |
| _version_ | 1828779583559696384 |
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| author | Ákos Tóth Attila Makai Laura Jánvári Ivelina Damjanova Márió Gajdács Edit Urbán |
| author_facet | Ákos Tóth Attila Makai Laura Jánvári Ivelina Damjanova Márió Gajdács Edit Urbán |
| author_sort | Ákos Tóth |
| collection | DOAJ |
| description | A carbapenem-resistant S. marcescens isolate was recovered from a patient with an inflammed pacemaker inplantation pocket from a Cardiac Surgery ward in a Hungarian University Hospital. Phenotypic tests and polymerase chain reaction (PCR) confirmed a very rare gene responsible for production of a carbapenemase (blaVIM-4), which was further characterized by Sanger-sequencing. The characterization of this S. marcescens strain emphasizes the ongoing emergence of novel or rare carbapenemases. Strains expressing a weak carbapenemase like this strain might go unrecognized by routine diagnostics due to low minimum inhibitory concentrations (MICs) for the bacterial strains producing such enzymes. |
| first_indexed | 2024-12-11T17:05:18Z |
| format | Article |
| id | doaj.art-e238667febef4cfe9bc162cbb5597f1b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-11T17:05:18Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e238667febef4cfe9bc162cbb5597f1b2022-12-22T00:57:43ZengElsevierHeliyon2405-84402020-06-0166e04231Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in HungaryÁkos Tóth0Attila Makai1Laura Jánvári2Ivelina Damjanova3Márió Gajdács4Edit Urbán5Department of Bacteriology, Mycology and Parasitology, National Institute of Public Health, 1097, Albert Flórián út 2-6, Budapest, HungaryDepartment of Internal Medicine, Faculty of Medicine, University of Szeged, 6720 Korányi fasor 8-10, Szeged, HungaryDepartment of Bacteriology, Mycology and Parasitology, National Institute of Public Health, 1097, Albert Flórián út 2-6, Budapest, HungaryDepartment of Bacteriology, Mycology and Parasitology, National Institute of Public Health, 1097, Albert Flórián út 2-6, Budapest, HungaryDepartment of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged; 6720 Eötvös utca 6, Szeged, Hungary; Corresponding author.Department of Public Health, Faculty of Medicine, University of Szeged; 6720 Dóm tér 10, Szeged, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, 7624 Szigeti út 12, Pécs, HungaryA carbapenem-resistant S. marcescens isolate was recovered from a patient with an inflammed pacemaker inplantation pocket from a Cardiac Surgery ward in a Hungarian University Hospital. Phenotypic tests and polymerase chain reaction (PCR) confirmed a very rare gene responsible for production of a carbapenemase (blaVIM-4), which was further characterized by Sanger-sequencing. The characterization of this S. marcescens strain emphasizes the ongoing emergence of novel or rare carbapenemases. Strains expressing a weak carbapenemase like this strain might go unrecognized by routine diagnostics due to low minimum inhibitory concentrations (MICs) for the bacterial strains producing such enzymes.http://www.sciencedirect.com/science/article/pii/S2405844020310756MicrobiologyBacteriaMicroorganismPublic healthInfectious diseasePharmacology |
| spellingShingle | Ákos Tóth Attila Makai Laura Jánvári Ivelina Damjanova Márió Gajdács Edit Urbán Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary Heliyon Microbiology Bacteria Microorganism Public health Infectious disease Pharmacology |
| title | Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary |
| title_full | Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary |
| title_fullStr | Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary |
| title_full_unstemmed | Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary |
| title_short | Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary |
| title_sort | characterization of a rare blavim 4 metallo β lactamase producing serratia marcescens clinical isolate in hungary |
| topic | Microbiology Bacteria Microorganism Public health Infectious disease Pharmacology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020310756 |
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