Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis

Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis

Abstract Background Rv3737 is the sole homologue of multifunctional transporter ThrE in Mycobacterium tuberculosis (Mtb). In this study, we aimed to investigate whether this transporter participates in vitro and in vivo survival of Mtb. Methods To characterize the role of Rv3737, we constructed and...

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Bibliographic Details
Main Authors: Qing Li, Zhangli Peng, Xuefeng Fu, Hong Wang, Zhaoliang Zhao, Yu Pang, Ling Chen
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Infectious Diseases
Subjects:
Rv3737
Mycobacterium tuberculosis
Virulence
Transporter
Online Access:https://doi.org/10.1186/s12879-021-06967-y

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