Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling

Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling

Abstract Background Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein 1 (Ufbp1), as putative targets of ubiquitin-fold modifier 1 (Ufm1), have been implicated in several pathogenesis-related signaling pathways. However, little is known about their functional roles in liver disease. Methods Hepa...

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Bibliographic Details
Main Authors: Fanghui Chen, Le Sheng, Tianci Zhou, Li Yan, Reid Loveless, Honglin Li, Yong Teng, Yafei Cai
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ufl1/Ufbp1
mTOR
Hepatic fibrosis
Fatty liver
HCC
Online Access:https://doi.org/10.1186/s13046-023-02681-6

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