The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication
Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple roles in various organs and tissues and facilitates their crosstalk. Here, we describe the current knowledge on the tissue- an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/4/562 |
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| author | Yulia Kargapolova Simon Geißen Ruiyuan Zheng Stephan Baldus Holger Winkels Matti Adam |
| author_facet | Yulia Kargapolova Simon Geißen Ruiyuan Zheng Stephan Baldus Holger Winkels Matti Adam |
| author_sort | Yulia Kargapolova |
| collection | DOAJ |
| description | Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple roles in various organs and tissues and facilitates their crosstalk. Here, we describe the current knowledge on the tissue- and lineage-specific expression of myeloperoxidase, its well-studied enzymatic activity and incoherently understood non-enzymatic role in various cell types and tissues. Further, we elaborate on Myeloperoxidase (MPO) in the complex context of cardiovascular disease, innate and autoimmune response, development and progression of cancer and neurodegenerative diseases. |
| first_indexed | 2024-03-10T12:36:12Z |
| format | Article |
| id | doaj.art-e23e18c3813b4cfc92141eea97c94539 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T12:36:12Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e23e18c3813b4cfc92141eea97c945392023-11-21T14:16:18ZengMDPI AGAntioxidants2076-39212021-04-0110456210.3390/antiox10040562The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory CommunicationYulia Kargapolova0Simon Geißen1Ruiyuan Zheng2Stephan Baldus3Holger Winkels4Matti Adam5Department III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyDepartment III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyDepartment III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyDepartment III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyDepartment III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyDepartment III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne, 50937 North Rhine-Westphalia, GermanyMyeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple roles in various organs and tissues and facilitates their crosstalk. Here, we describe the current knowledge on the tissue- and lineage-specific expression of myeloperoxidase, its well-studied enzymatic activity and incoherently understood non-enzymatic role in various cell types and tissues. Further, we elaborate on Myeloperoxidase (MPO) in the complex context of cardiovascular disease, innate and autoimmune response, development and progression of cancer and neurodegenerative diseases.https://www.mdpi.com/2076-3921/10/4/562myeloperoxidaseoxidative burstNETscellular internalizationimmune responsecancer |
| spellingShingle | Yulia Kargapolova Simon Geißen Ruiyuan Zheng Stephan Baldus Holger Winkels Matti Adam The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication Antioxidants myeloperoxidase oxidative burst NETs cellular internalization immune response cancer |
| title | The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication |
| title_full | The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication |
| title_fullStr | The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication |
| title_full_unstemmed | The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication |
| title_short | The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication |
| title_sort | enzymatic and non enzymatic function of myeloperoxidase mpo in inflammatory communication |
| topic | myeloperoxidase oxidative burst NETs cellular internalization immune response cancer |
| url | https://www.mdpi.com/2076-3921/10/4/562 |
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