Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis
Background: Lupus nephritis (LN) is a debilitating complication of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard for evaluating LN. Serum C4d is a potential non-invasive method for evaluating LN. The purpose of this study was to evaluate the value of C4d in the assessment of...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2023-03-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-2790-en.html |
| _version_ | 1797834474836197376 |
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| author | Nayyereh Saadati Maryam Miri |
| author_facet | Nayyereh Saadati Maryam Miri |
| author_sort | Nayyereh Saadati |
| collection | DOAJ |
| description | Background: Lupus nephritis (LN) is a debilitating complication of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard for evaluating LN. Serum C4d is a potential non-invasive method for evaluating LN. The purpose of this study was to evaluate the value of C4d in the assessment of LN.
Methods: This cross-sectional study was conducted on patients with LN who were referred to a tertiary hospital in Mashhad, Iran. Subjects were divided into four groups including LN, SLE without renal involvement, chronic kidney disease (CKD) and healthy controls. Serum C4d. creatinine, and glomerular filtration rate (GFR) were assessed for all subjects.
Results: Forty-three subjects (11, 25.6% healthy controls, 9, 20.9% SLE patients, 13, 30.2% LN and 10, 23.3% CKD patients) participated in this study. CKD group were significantly older than other groups (p>0.05). There was a significant difference in gender distribution between groups (p<0.001). Median serum C4d were 0.6 in healthy controls and CKD group and 0.3 in SLE and LN groups. There was no significant difference in serum C4d between groups (p=0.503).
Conclusion: The findings of this study indicated that serum C4d might not be a promising marker in the assessment of LN. These findings should be documented by further multicenter studies. |
| first_indexed | 2024-04-09T14:38:30Z |
| format | Article |
| id | doaj.art-e240e4422847473abd372c910db81e5a |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-09T14:38:30Z |
| publishDate | 2023-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-e240e4422847473abd372c910db81e5a2023-05-03T10:46:23ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722023-03-01142231236Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritisNayyereh Saadati0Maryam Miri1 Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Kidney transplantation complication research center,Mashhad university of medical sciences,mashhad,Iran Background: Lupus nephritis (LN) is a debilitating complication of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard for evaluating LN. Serum C4d is a potential non-invasive method for evaluating LN. The purpose of this study was to evaluate the value of C4d in the assessment of LN. Methods: This cross-sectional study was conducted on patients with LN who were referred to a tertiary hospital in Mashhad, Iran. Subjects were divided into four groups including LN, SLE without renal involvement, chronic kidney disease (CKD) and healthy controls. Serum C4d. creatinine, and glomerular filtration rate (GFR) were assessed for all subjects. Results: Forty-three subjects (11, 25.6% healthy controls, 9, 20.9% SLE patients, 13, 30.2% LN and 10, 23.3% CKD patients) participated in this study. CKD group were significantly older than other groups (p>0.05). There was a significant difference in gender distribution between groups (p<0.001). Median serum C4d were 0.6 in healthy controls and CKD group and 0.3 in SLE and LN groups. There was no significant difference in serum C4d between groups (p=0.503). Conclusion: The findings of this study indicated that serum C4d might not be a promising marker in the assessment of LN. These findings should be documented by further multicenter studies.http://caspjim.com/article-1-2790-en.htmllupus nephritissystemic lupus erythematosusc4d |
| spellingShingle | Nayyereh Saadati Maryam Miri Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis Caspian Journal of Internal Medicine lupus nephritis systemic lupus erythematosus c4d |
| title | Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| title_full | Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| title_fullStr | Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| title_full_unstemmed | Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| title_short | Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| title_sort | evaluation of serum c4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis |
| topic | lupus nephritis systemic lupus erythematosus c4d |
| url | http://caspjim.com/article-1-2790-en.html |
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