Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study
Background: Macular drusen formation and angiogenesis are the two chief processes associated with age-related macular degeneration. Adropin and vascular endothelial growth factor receptor-2 (VEGFR-2) may be involved in these pathologies. By altering lipid metabolism, adropin may contribute in the ea...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=9;spage=4875;epage=4879;aulast=Neethu |
| _version_ | 1831836941889306624 |
|---|---|
| author | Areekulangara Neethu Kuppuswami Jayashree Gandhipuram Periyasamy Senthilkumar K Ramesh Babu Mehalingam Vadivelan |
| author_facet | Areekulangara Neethu Kuppuswami Jayashree Gandhipuram Periyasamy Senthilkumar K Ramesh Babu Mehalingam Vadivelan |
| author_sort | Areekulangara Neethu |
| collection | DOAJ |
| description | Background: Macular drusen formation and angiogenesis are the two chief processes associated with age-related macular degeneration. Adropin and vascular endothelial growth factor receptor-2 (VEGFR-2) may be involved in these pathologies. By altering lipid metabolism, adropin may contribute in the early stages of age-related macular degeneration (AMD). VEGFR-2 may participate in the later form of AMD, by promoting angiogenesis. This study compared the circulatory levels of adropin and VEGFR-2 in AMD and patients without AMD and assessed their association with disease severity, to understand their possible role in AMD. Objectives: This study aimed to assess and compare the serum levels of adropin and VEGFR-2 in patients with AMD and type 2 diabetes patients without AMD, and, to investigate the correlation between these two parameters with disease severity. Methods: Our study involves two groups of 39 each. Group A (age-related macular degeneration) and Group B (diabetes patients without age-related macular degeneration). Routine parameters fasting blood sugar (FBS), lipid profile, and liver function tests (LFT) were estimated by using autoanalyzer. Serum adropin and VEGFR-2 were assessed by ELISA. Results: Among the basic parameters, systolic blood pressure and fasting blood glucose alone were significantly different across the groups. We did not find significant alterations in adropin and VEGFR-2 levels between the study groups. Our lipid profile parameters (triglycerides and total cholesterol) have significant positive association. VEGFR-2 showed a positive correlation with the severity of AMD. Adropin did not exhibit any correlation with disease severity and with VEGFR-2. Conclusion: We could not find any observable alterations of statistical significance, in adropin and VEGFR-2 levels. VEGFR-2's correlation with disease severity could be important. Adropin might have subtler roles in AMD, though not evident from our study, and requires a deeper observation at the molecular level to elucidate its function. |
| first_indexed | 2024-12-23T05:06:02Z |
| format | Article |
| id | doaj.art-e241c7383d094e148505c32ac35b4292 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-23T05:06:02Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-e241c7383d094e148505c32ac35b42922022-12-21T17:59:06ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632020-01-01994875487910.4103/jfmpc.jfmpc_813_20Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional studyAreekulangara NeethuKuppuswami JayashreeGandhipuram Periyasamy SenthilkumarK Ramesh BabuMehalingam VadivelanBackground: Macular drusen formation and angiogenesis are the two chief processes associated with age-related macular degeneration. Adropin and vascular endothelial growth factor receptor-2 (VEGFR-2) may be involved in these pathologies. By altering lipid metabolism, adropin may contribute in the early stages of age-related macular degeneration (AMD). VEGFR-2 may participate in the later form of AMD, by promoting angiogenesis. This study compared the circulatory levels of adropin and VEGFR-2 in AMD and patients without AMD and assessed their association with disease severity, to understand their possible role in AMD. Objectives: This study aimed to assess and compare the serum levels of adropin and VEGFR-2 in patients with AMD and type 2 diabetes patients without AMD, and, to investigate the correlation between these two parameters with disease severity. Methods: Our study involves two groups of 39 each. Group A (age-related macular degeneration) and Group B (diabetes patients without age-related macular degeneration). Routine parameters fasting blood sugar (FBS), lipid profile, and liver function tests (LFT) were estimated by using autoanalyzer. Serum adropin and VEGFR-2 were assessed by ELISA. Results: Among the basic parameters, systolic blood pressure and fasting blood glucose alone were significantly different across the groups. We did not find significant alterations in adropin and VEGFR-2 levels between the study groups. Our lipid profile parameters (triglycerides and total cholesterol) have significant positive association. VEGFR-2 showed a positive correlation with the severity of AMD. Adropin did not exhibit any correlation with disease severity and with VEGFR-2. Conclusion: We could not find any observable alterations of statistical significance, in adropin and VEGFR-2 levels. VEGFR-2's correlation with disease severity could be important. Adropin might have subtler roles in AMD, though not evident from our study, and requires a deeper observation at the molecular level to elucidate its function.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=9;spage=4875;epage=4879;aulast=Neethuadropinage-related macular degenerationangiogenesisdrusenvegfr-2 |
| spellingShingle | Areekulangara Neethu Kuppuswami Jayashree Gandhipuram Periyasamy Senthilkumar K Ramesh Babu Mehalingam Vadivelan Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study Journal of Family Medicine and Primary Care adropin age-related macular degeneration angiogenesis drusen vegfr-2 |
| title | Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study |
| title_full | Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study |
| title_fullStr | Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study |
| title_full_unstemmed | Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study |
| title_short | Circulating adropin and vascular endothelial growth factor receptor-2 levels in age-related macular degeneration and T2DM patients—A cross-sectional study |
| title_sort | circulating adropin and vascular endothelial growth factor receptor 2 levels in age related macular degeneration and t2dm patients a cross sectional study |
| topic | adropin age-related macular degeneration angiogenesis drusen vegfr-2 |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=9;spage=4875;epage=4879;aulast=Neethu |
| work_keys_str_mv | AT areekulangaraneethu circulatingadropinandvascularendothelialgrowthfactorreceptor2levelsinagerelatedmaculardegenerationandt2dmpatientsacrosssectionalstudy AT kuppuswamijayashree circulatingadropinandvascularendothelialgrowthfactorreceptor2levelsinagerelatedmaculardegenerationandt2dmpatientsacrosssectionalstudy AT gandhipuramperiyasamysenthilkumar circulatingadropinandvascularendothelialgrowthfactorreceptor2levelsinagerelatedmaculardegenerationandt2dmpatientsacrosssectionalstudy AT krameshbabu circulatingadropinandvascularendothelialgrowthfactorreceptor2levelsinagerelatedmaculardegenerationandt2dmpatientsacrosssectionalstudy AT mehalingamvadivelan circulatingadropinandvascularendothelialgrowthfactorreceptor2levelsinagerelatedmaculardegenerationandt2dmpatientsacrosssectionalstudy |