Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders?
Discovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration. Upon diverse extracellular and intracellular stimuli, Hippo signaling regulates stemness, cell proliferation and apopt...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00715/full |
| _version_ | 1817998279540998144 |
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| author | Jens Stepan Elmira Anderzhanova Nils C. Gassen |
| author_facet | Jens Stepan Elmira Anderzhanova Nils C. Gassen |
| author_sort | Jens Stepan |
| collection | DOAJ |
| description | Discovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration. Upon diverse extracellular and intracellular stimuli, Hippo signaling regulates stemness, cell proliferation and apoptosis by a well-conserved signaling cascade, and disruption of these systems has been implicated in cancer as well as metabolic and neurodegenerative diseases. The central role of Hippo signaling in cell biology also results in prominent links to stress-regulated pathways. Genetic variations, epigenetically provoked upregulation of Hippo pathway members and dysregulation of cellular processes implicated in learning and memory, are linked to an increased risk of stress-related psychiatric disorders (SRPDs). In this review, we summarize recent findings, supporting the role of Hippo signaling in SRPDs by canonical and non-canonical Hippo pathway interactions. |
| first_indexed | 2024-04-14T02:50:43Z |
| format | Article |
| id | doaj.art-e242d999ebbf49558cdc60df44fc8241 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-14T02:50:43Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e242d999ebbf49558cdc60df44fc82412022-12-22T02:16:18ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-12-01910.3389/fpsyt.2018.00715430721Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders?Jens Stepan0Elmira Anderzhanova1Nils C. Gassen2Department Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, GermanyClinic and Polyclinic of Psychiatry and Psychotherapy, Bonn University Clinic, Bonn, GermanyClinic and Polyclinic of Psychiatry and Psychotherapy, Bonn University Clinic, Bonn, GermanyDiscovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration. Upon diverse extracellular and intracellular stimuli, Hippo signaling regulates stemness, cell proliferation and apoptosis by a well-conserved signaling cascade, and disruption of these systems has been implicated in cancer as well as metabolic and neurodegenerative diseases. The central role of Hippo signaling in cell biology also results in prominent links to stress-regulated pathways. Genetic variations, epigenetically provoked upregulation of Hippo pathway members and dysregulation of cellular processes implicated in learning and memory, are linked to an increased risk of stress-related psychiatric disorders (SRPDs). In this review, we summarize recent findings, supporting the role of Hippo signaling in SRPDs by canonical and non-canonical Hippo pathway interactions.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00715/fullhippo pathwayKIBRApsychophysiological stresssynaptic plasticityglucocorticoidsGPCRs |
| spellingShingle | Jens Stepan Elmira Anderzhanova Nils C. Gassen Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? Frontiers in Psychiatry hippo pathway KIBRA psychophysiological stress synaptic plasticity glucocorticoids GPCRs |
| title | Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? |
| title_full | Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? |
| title_fullStr | Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? |
| title_full_unstemmed | Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? |
| title_short | Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders? |
| title_sort | hippo signaling emerging pathway in stress related psychiatric disorders |
| topic | hippo pathway KIBRA psychophysiological stress synaptic plasticity glucocorticoids GPCRs |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00715/full |
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