Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients
<b>Objectives:</b> Weight loss improves the liver pathophysiological status of nonalcoholic fatty liver disease (NAFLD) patients. However, there are few studies that investigate the accurate relationships between nutritional intake and disease progression in NAFLD patients. <b>Meth...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3453 |
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| author | Yoshihiro Kamada Hirokazu Takahashi Yuji Ogawa Hideyuki Hyogo Kyoko Nakamura Tomomi Yada Norihiko Asada Tomomi Bando Hanako Sawano Mika Hatanaka Takako Tosa Mika Ando Etsuko Hikita Kaori Yoshida Masahiro Koseki Yoshio Sumida Kazuhisa Maeda Makoto Fujii Shinichi Aishima Mariko Hayakawa Atsushi Nakajima |
| author_facet | Yoshihiro Kamada Hirokazu Takahashi Yuji Ogawa Hideyuki Hyogo Kyoko Nakamura Tomomi Yada Norihiko Asada Tomomi Bando Hanako Sawano Mika Hatanaka Takako Tosa Mika Ando Etsuko Hikita Kaori Yoshida Masahiro Koseki Yoshio Sumida Kazuhisa Maeda Makoto Fujii Shinichi Aishima Mariko Hayakawa Atsushi Nakajima |
| author_sort | Yoshihiro Kamada |
| collection | DOAJ |
| description | <b>Objectives:</b> Weight loss improves the liver pathophysiological status of nonalcoholic fatty liver disease (NAFLD) patients. However, there are few studies that investigate the accurate relationships between nutritional intake and disease progression in NAFLD patients. <b>Methods:</b> A total of 37 biopsy-confirmed NAFLD patients were enrolled in this study. Clinical and nutritional control data of 5074 persons were obtained from the National Institute of Health and Nutrition. Each NAFLD subject recorded dietary intake for seven consecutive days using a dietary questionnaire and photographs of each meal. A dietitian analyzed and quantified the nutritional data in each patient. We further analyzed the nutritional intake of NAFLD patients in three groups according to the following criteria: (1) liver fibrosis degree (advanced, early), (2) gender (male, female), and (3) body mass index (BMI) (high, low). <b>Results:</b> Excesses or deficiencies of multiple nutrients were found in NAFLD patients compared with control subjects. In addition, there were variations in nutritional intake. (1) The intake of vitamins A, B<sub>6</sub>, and E, pantothenic acid, soluble dietary fiber, and salt was lower in the advanced fibrosis group than in the early fibrosis group. (2) Fat intake was higher in male patients, and dietary fiber intake was lower in both male and female patients compared with control subjects. (3) Saturated fatty acid intake was higher, and copper and vitamin E intakes were lower in patients with high BMI than with low BMI. <b>Conclusions:</b> Our study demonstrates that differences were found in some nutrient intake of NAFLD patients and controls and according to the severity of the conditions (liver fibrosis degree, BMI). |
| first_indexed | 2024-03-10T01:26:19Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:19Z |
| publishDate | 2022-08-01 |
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| series | Nutrients |
| spelling | doaj.art-e24378144de244399734973031a30c3c2023-11-23T13:50:44ZengMDPI AGNutrients2072-66432022-08-011417345310.3390/nu14173453Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD PatientsYoshihiro Kamada0Hirokazu Takahashi1Yuji Ogawa2Hideyuki Hyogo3Kyoko Nakamura4Tomomi Yada5Norihiko Asada6Tomomi Bando7Hanako Sawano8Mika Hatanaka9Takako Tosa10Mika Ando11Etsuko Hikita12Kaori Yoshida13Masahiro Koseki14Yoshio Sumida15Kazuhisa Maeda16Makoto Fujii17Shinichi Aishima18Mariko Hayakawa19Atsushi Nakajima20Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, JapanLiver Center, Saga University Hospital, Faculty of Medicine, Saga University, Saga 840-8502, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine Graduate School of Medicine, 3-9, Fukuura, Kanazawa-Ku, Yokohama 236-0004, JapanDepartment of Gastroenterology, JA Hiroshima Kouseiren General Hospital, Hatsukaichi, Hiroshima 738-8503, JapanDepartment of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, JapanLiver Center, Saga University Hospital, Faculty of Medicine, Saga University, Saga 840-8502, JapanDepartment of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women’s University, Kobe 658-0001, JapanMiwa Home Clinic, Tokai 477-0031, JapanTakata Diabetes Internal Medicine Clinic, Kawasaki 210-0817, JapanAkihabara Station Clinic, Tokyo 101-0041, JapanMITO Research Center for Integrative Healthcare, Gifu 502-0013, JapanMITO Research Center for Integrative Healthcare, Gifu 502-0013, JapanMedical Corporation Yamashita Hospital, Ichinomiya 491-0913, JapanSakanoichi Hospital, Sakanoichi, Oita 870-0307, JapanDivision of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, JapanDivision of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Nagakute 480-1103, JapanLongwood Maeda Clinic, Suita 565-0874, JapanDivision of Health Sciences, Osaka University Graduate School of Medicine, Suita 565-0871, JapanDepartment of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga 840-8502, JapanDepartment of Health and Nutrition Sciences, Faculty of Human Life Sciences, Nagoya University of Economics, Nagoya 484-0047, JapanDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine Graduate School of Medicine, 3-9, Fukuura, Kanazawa-Ku, Yokohama 236-0004, Japan<b>Objectives:</b> Weight loss improves the liver pathophysiological status of nonalcoholic fatty liver disease (NAFLD) patients. However, there are few studies that investigate the accurate relationships between nutritional intake and disease progression in NAFLD patients. <b>Methods:</b> A total of 37 biopsy-confirmed NAFLD patients were enrolled in this study. Clinical and nutritional control data of 5074 persons were obtained from the National Institute of Health and Nutrition. Each NAFLD subject recorded dietary intake for seven consecutive days using a dietary questionnaire and photographs of each meal. A dietitian analyzed and quantified the nutritional data in each patient. We further analyzed the nutritional intake of NAFLD patients in three groups according to the following criteria: (1) liver fibrosis degree (advanced, early), (2) gender (male, female), and (3) body mass index (BMI) (high, low). <b>Results:</b> Excesses or deficiencies of multiple nutrients were found in NAFLD patients compared with control subjects. In addition, there were variations in nutritional intake. (1) The intake of vitamins A, B<sub>6</sub>, and E, pantothenic acid, soluble dietary fiber, and salt was lower in the advanced fibrosis group than in the early fibrosis group. (2) Fat intake was higher in male patients, and dietary fiber intake was lower in both male and female patients compared with control subjects. (3) Saturated fatty acid intake was higher, and copper and vitamin E intakes were lower in patients with high BMI than with low BMI. <b>Conclusions:</b> Our study demonstrates that differences were found in some nutrient intake of NAFLD patients and controls and according to the severity of the conditions (liver fibrosis degree, BMI).https://www.mdpi.com/2072-6643/14/17/3453biopsy-confirmed NAFLDbiases in nutritional intakevitamin A intakecopper intake |
| spellingShingle | Yoshihiro Kamada Hirokazu Takahashi Yuji Ogawa Hideyuki Hyogo Kyoko Nakamura Tomomi Yada Norihiko Asada Tomomi Bando Hanako Sawano Mika Hatanaka Takako Tosa Mika Ando Etsuko Hikita Kaori Yoshida Masahiro Koseki Yoshio Sumida Kazuhisa Maeda Makoto Fujii Shinichi Aishima Mariko Hayakawa Atsushi Nakajima Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients Nutrients biopsy-confirmed NAFLD biases in nutritional intake vitamin A intake copper intake |
| title | Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients |
| title_full | Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients |
| title_fullStr | Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients |
| title_full_unstemmed | Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients |
| title_short | Characterization of Nutrient Intake in Biopsy-Confirmed NAFLD Patients |
| title_sort | characterization of nutrient intake in biopsy confirmed nafld patients |
| topic | biopsy-confirmed NAFLD biases in nutritional intake vitamin A intake copper intake |
| url | https://www.mdpi.com/2072-6643/14/17/3453 |
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