CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways

CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways

Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade have shown promising signs of activity in immune checkpoint...

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Bibliographic Details
Main Authors: Michael B. Murphy, Laura Vitale, Shukai Xia, Zeyu Peng, Thomas O’Neill, Jay Lillquist, Anna Wasiuk, Jeff Weidlick, Jenifer Widger, Laura Mills-Chen, Andrea Crocker, Colleen Patterson, James Boyer, April R. Baronas, Mingjiu Chen, Hugh M. Davis, Mark Ma, Joel Goldstein, Lawrence J. Thomas, Diego Alvarado, Henry C. Marsh, Tibor Keler
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Immuno
Subjects:
macrophages
dendritic cells
T cells
immunotherapy
cancer
bispecific antibodies
Online Access:https://www.mdpi.com/2673-5601/3/3/18

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