S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury
Sepsis, the foremost contributor to mortality in intensive care unit patients, arises from an uncontrolled systemic response to invading infections, resulting in extensive harm across multiple organs and systems. Recently, S100A8/A9 has emerged as a promising biomarker for sepsis and sepsis-induced...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223014725 |
| _version_ | 1797630712422072320 |
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| author | Qian Wang Gangyu Long Hong Luo Xiqun Zhu Yang Han You Shang Dingyu Zhang Rui Gong |
| author_facet | Qian Wang Gangyu Long Hong Luo Xiqun Zhu Yang Han You Shang Dingyu Zhang Rui Gong |
| author_sort | Qian Wang |
| collection | DOAJ |
| description | Sepsis, the foremost contributor to mortality in intensive care unit patients, arises from an uncontrolled systemic response to invading infections, resulting in extensive harm across multiple organs and systems. Recently, S100A8/A9 has emerged as a promising biomarker for sepsis and sepsis-induced organ injury, and targeting S100A8/A9 appeared to ameliorate inflammation-induced tissue damage and improve adverse outcomes. S100A8/A9, a calcium-binding heterodimer mainly found in neutrophils and monocytes, serves as a causative molecule with pro-inflammatory and immunosuppressive properties, which are vital in the pathogenesis of sepsis. Therefore, improving our comprehension of how S100A8/A9 acts as a pathological player in the development of sepsis is imperative for advancing research on sepsis. Our review is the first-to the best of our knowledge-to discuss the biology of S100A8/A9 and its release mechanisms, summarize recent advances concerning the vital roles of S100A8/A9 in sepsis and the consequential organ damage, and underscore its potential as a promising diagnostic biomarker and therapeutic target for sepsis. |
| first_indexed | 2024-03-11T11:11:00Z |
| format | Article |
| id | doaj.art-e244c9484500461e815ef64ce9d49027 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:11:00Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e244c9484500461e815ef64ce9d490272023-11-12T04:38:51ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115674S100A8/A9: An emerging player in sepsis and sepsis-induced organ injuryQian Wang0Gangyu Long1Hong Luo2Xiqun Zhu3Yang Han4You Shang5Dingyu Zhang6Rui Gong7Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430023, ChinaWuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430023, ChinaWuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430023, ChinaHubei Cancer Hospital, Tongji Medical College, HUST, Wuhan 430079, ChinaCenter for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan 430023, ChinaDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, HUST, Wuhan 430030, China; Corresponding authors.Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430023, China; Hubei Clinical Research Center for Infectious Diseases, Wuhan 430023, China; Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences, Wuhan 430023, China; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, Wuhan 430023, China; Corresponding author at: Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1 YinTan Road, HuBei, Wuhan 430023, China.The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Corresponding authors.Sepsis, the foremost contributor to mortality in intensive care unit patients, arises from an uncontrolled systemic response to invading infections, resulting in extensive harm across multiple organs and systems. Recently, S100A8/A9 has emerged as a promising biomarker for sepsis and sepsis-induced organ injury, and targeting S100A8/A9 appeared to ameliorate inflammation-induced tissue damage and improve adverse outcomes. S100A8/A9, a calcium-binding heterodimer mainly found in neutrophils and monocytes, serves as a causative molecule with pro-inflammatory and immunosuppressive properties, which are vital in the pathogenesis of sepsis. Therefore, improving our comprehension of how S100A8/A9 acts as a pathological player in the development of sepsis is imperative for advancing research on sepsis. Our review is the first-to the best of our knowledge-to discuss the biology of S100A8/A9 and its release mechanisms, summarize recent advances concerning the vital roles of S100A8/A9 in sepsis and the consequential organ damage, and underscore its potential as a promising diagnostic biomarker and therapeutic target for sepsis.http://www.sciencedirect.com/science/article/pii/S0753332223014725S100A8/A9ImmunityBiomarkerTherapeutic targetSepsisSepsis-induced organ injury |
| spellingShingle | Qian Wang Gangyu Long Hong Luo Xiqun Zhu Yang Han You Shang Dingyu Zhang Rui Gong S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury Biomedicine & Pharmacotherapy S100A8/A9 Immunity Biomarker Therapeutic target Sepsis Sepsis-induced organ injury |
| title | S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury |
| title_full | S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury |
| title_fullStr | S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury |
| title_full_unstemmed | S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury |
| title_short | S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury |
| title_sort | s100a8 a9 an emerging player in sepsis and sepsis induced organ injury |
| topic | S100A8/A9 Immunity Biomarker Therapeutic target Sepsis Sepsis-induced organ injury |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223014725 |
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