Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19
Background The extent of cardiac dysfunction post‐COVID‐19 varies, and there is a lack of data on arrhythmic burden. Methods and Results This was a combined multicenter prospective cohort study and cross‐sectional case‐control study. Cardiac function assessed by echocardiography in patients with COV...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.023473 |
| _version_ | 1797631002814709760 |
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| author | Charlotte B. Ingul Jostein Grimsmo Albulena Mecinaj Divna Trebinjac Magnus Berger Nossen Simon Andrup Bjørnar Grenne Håvard Dalen Gunnar Einvik Knut Stavem Turid Follestad Tony Josefsen Torbjørn Omland Torstein Jensen |
| author_facet | Charlotte B. Ingul Jostein Grimsmo Albulena Mecinaj Divna Trebinjac Magnus Berger Nossen Simon Andrup Bjørnar Grenne Håvard Dalen Gunnar Einvik Knut Stavem Turid Follestad Tony Josefsen Torbjørn Omland Torstein Jensen |
| author_sort | Charlotte B. Ingul |
| collection | DOAJ |
| description | Background The extent of cardiac dysfunction post‐COVID‐19 varies, and there is a lack of data on arrhythmic burden. Methods and Results This was a combined multicenter prospective cohort study and cross‐sectional case‐control study. Cardiac function assessed by echocardiography in patients with COVID‐19 3 to 4 months after hospital discharge was compared with matched controls. The 24‐hour ECGs were recorded in patients with COVID‐19. A total of 204 patients with COVID‐19 consented to participate (mean age, 58.5 years; 44% women), and 204 controls were included (mean age, 58.4 years; 44% women). Patients with COVID‐19 had worse right ventricle free wall longitudinal strain (adjusted estimated mean difference, 1.5 percentage points; 95% CI, −2.6 to −0.5; P=0.005) and lower tricuspid annular plane systolic excursion (−0.10 cm; 95% CI, −0.14 to −0.05; P<0.001) and cardiac index (−0.26 L/min per m2; 95% CI, −0.40 to −0.12; P<0.001), but slightly better left ventricle global strain (−0.8 percentage points; 95% CI, 0.2–1.3; P=0.008) compared with controls. Reduced diastolic function was twice as common compared with controls (60 [30%] versus 29 [15%], respectively; odds ratio, 2.4; P=0.001). Having dyspnea or fatigue were not associated with cardiac function. Right ventricle free wall longitudinal strain was worse after intensive care treatment. Arrhythmias were found in 27% of the patients, mainly premature ventricular contractions and nonsustained ventricular tachycardia (18% and 5%, respectively). Conclusions At 3 months after hospital discharge with COVID‐19, right ventricular function was mildly impaired, and diastolic dysfunction was twice as common compared with controls. There was little evidence for an association between cardiac function and intensive care treatment, dyspnea, or fatigue. Ventricular arrhythmias were common, but the clinical importance is unknown. Registration URL: http://clinicaltrials.gov. Unique Identifier: NCT04535154. |
| first_indexed | 2024-03-11T11:15:57Z |
| format | Article |
| id | doaj.art-e247302c49fd4770b6890b18f7542892 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-11T11:15:57Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-e247302c49fd4770b6890b18f75428922023-11-11T04:49:37ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-02-0111310.1161/JAHA.121.023473Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19Charlotte B. Ingul0Jostein Grimsmo1Albulena Mecinaj2Divna Trebinjac3Magnus Berger Nossen4Simon Andrup5Bjørnar Grenne6Håvard Dalen7Gunnar Einvik8Knut Stavem9Turid Follestad10Tony Josefsen11Torbjørn Omland12Torstein Jensen13Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim NorwayThe National Association for Heart, Lung diseases Hospital Gardermoen Jessheim NorwayDepartment of Cardiology Division of Medicine Akershus University Hospital Lørenskog NorwayThe National Association for Heart, Lung diseases Hospital Gardermoen Jessheim NorwayDepartment of Cardiology Østfold Hospital Trust Kalnes Grålum NorwayDepartment of Cardiology Østfold Hospital Trust Kalnes Grålum NorwayDepartment of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim NorwayDepartment of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim NorwayPulmonary Department Akershus University Hospital Lørenskog NorwayPulmonary Department Akershus University Hospital Lørenskog NorwayDepartment of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim NorwayDepartment of Cardiology Østfold Hospital Trust Kalnes Grålum NorwayDepartment of Cardiology Division of Medicine Akershus University Hospital Lørenskog NorwayDepartment of Cardiology Oslo University Hospital Ullevål Oslo NorwayBackground The extent of cardiac dysfunction post‐COVID‐19 varies, and there is a lack of data on arrhythmic burden. Methods and Results This was a combined multicenter prospective cohort study and cross‐sectional case‐control study. Cardiac function assessed by echocardiography in patients with COVID‐19 3 to 4 months after hospital discharge was compared with matched controls. The 24‐hour ECGs were recorded in patients with COVID‐19. A total of 204 patients with COVID‐19 consented to participate (mean age, 58.5 years; 44% women), and 204 controls were included (mean age, 58.4 years; 44% women). Patients with COVID‐19 had worse right ventricle free wall longitudinal strain (adjusted estimated mean difference, 1.5 percentage points; 95% CI, −2.6 to −0.5; P=0.005) and lower tricuspid annular plane systolic excursion (−0.10 cm; 95% CI, −0.14 to −0.05; P<0.001) and cardiac index (−0.26 L/min per m2; 95% CI, −0.40 to −0.12; P<0.001), but slightly better left ventricle global strain (−0.8 percentage points; 95% CI, 0.2–1.3; P=0.008) compared with controls. Reduced diastolic function was twice as common compared with controls (60 [30%] versus 29 [15%], respectively; odds ratio, 2.4; P=0.001). Having dyspnea or fatigue were not associated with cardiac function. Right ventricle free wall longitudinal strain was worse after intensive care treatment. Arrhythmias were found in 27% of the patients, mainly premature ventricular contractions and nonsustained ventricular tachycardia (18% and 5%, respectively). Conclusions At 3 months after hospital discharge with COVID‐19, right ventricular function was mildly impaired, and diastolic dysfunction was twice as common compared with controls. There was little evidence for an association between cardiac function and intensive care treatment, dyspnea, or fatigue. Ventricular arrhythmias were common, but the clinical importance is unknown. Registration URL: http://clinicaltrials.gov. Unique Identifier: NCT04535154.https://www.ahajournals.org/doi/10.1161/JAHA.121.023473arrhythmiascardiac functionCOVID‐19dyspneaintensive care |
| spellingShingle | Charlotte B. Ingul Jostein Grimsmo Albulena Mecinaj Divna Trebinjac Magnus Berger Nossen Simon Andrup Bjørnar Grenne Håvard Dalen Gunnar Einvik Knut Stavem Turid Follestad Tony Josefsen Torbjørn Omland Torstein Jensen Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease arrhythmias cardiac function COVID‐19 dyspnea intensive care |
| title | Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 |
| title_full | Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 |
| title_fullStr | Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 |
| title_full_unstemmed | Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 |
| title_short | Cardiac Dysfunction and Arrhythmias 3 Months After Hospitalization for COVID‐19 |
| title_sort | cardiac dysfunction and arrhythmias 3 months after hospitalization for covid 19 |
| topic | arrhythmias cardiac function COVID‐19 dyspnea intensive care |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.023473 |
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