Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of acute myocardial infarction are still high. Reperfusion injuries are inevitable due to the generation of reactive oxygen species (ROS) and apoptosis of cardiac muscl...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2022-01-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21002899 |
| _version_ | 1797203671646208000 |
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| author | Tianjiao Zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai |
| author_facet | Tianjiao Zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai |
| author_sort | Tianjiao Zhao |
| collection | DOAJ |
| description | Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of acute myocardial infarction are still high. Reperfusion injuries are inevitable due to the generation of reactive oxygen species (ROS) and apoptosis of cardiac muscle cells. However, many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration, such as short half-life, low stability, low bioavailability, and side effects for treatment myocardial ischemia reperfusion injury. Therefore, it is necessary to develop effective drugs and technologies to address this issue. Fortunately, nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury. Compared with traditional drugs, nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’ size, shape, and material characteristics. In this review, the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed. Furthermore, we summarized the applications of ROS-based nanoparticles, highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury. |
| first_indexed | 2024-04-24T08:23:02Z |
| format | Article |
| id | doaj.art-e247d0c9c2a34d90aedf0fdc2ef52017 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:23:02Z |
| publishDate | 2022-01-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Bioactive Materials |
| spelling | doaj.art-e247d0c9c2a34d90aedf0fdc2ef520172024-04-17T00:26:38ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-01-0174772Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuriesTianjiao Zhao0Wei Wu1Lihua Sui2Qiong Huang3Yayun Nan4Jianhua Liu5Kelong Ai6Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410087, China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410087, ChinaDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, 410087, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410087, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410087, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410087, China; Corresponding author. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410087, China.Geriatric Medical Center, Ningxia People's Hospital, Yinchuan, 750003, ChinaDepartment of Radiology, The Second Hospital of Jilin University, Changchun, 130041, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410008, China; Corresponding author. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China.Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of acute myocardial infarction are still high. Reperfusion injuries are inevitable due to the generation of reactive oxygen species (ROS) and apoptosis of cardiac muscle cells. However, many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration, such as short half-life, low stability, low bioavailability, and side effects for treatment myocardial ischemia reperfusion injury. Therefore, it is necessary to develop effective drugs and technologies to address this issue. Fortunately, nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury. Compared with traditional drugs, nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’ size, shape, and material characteristics. In this review, the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed. Furthermore, we summarized the applications of ROS-based nanoparticles, highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.http://www.sciencedirect.com/science/article/pii/S2452199X21002899Reactive oxygen speciesMyocardial ischemia reperfusion injuryNano-enzymeNanocarrierAntioxidant therapy |
| spellingShingle | Tianjiao Zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries Bioactive Materials Reactive oxygen species Myocardial ischemia reperfusion injury Nano-enzyme Nanocarrier Antioxidant therapy |
| title | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| title_full | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| title_fullStr | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| title_full_unstemmed | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| title_short | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| title_sort | reactive oxygen species based nanomaterials for the treatment of myocardial ischemia reperfusion injuries |
| topic | Reactive oxygen species Myocardial ischemia reperfusion injury Nano-enzyme Nanocarrier Antioxidant therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21002899 |
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