Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability
Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/12/3557 |
| _version_ | 1797530560051019776 |
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| author | Rosa Edith Grijalva-Guiza Aura Matilde Jiménez-Garduño Luis Ricardo Hernández |
| author_facet | Rosa Edith Grijalva-Guiza Aura Matilde Jiménez-Garduño Luis Ricardo Hernández |
| author_sort | Rosa Edith Grijalva-Guiza |
| collection | DOAJ |
| description | Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be regulated by redox potential, it is expected that during the onset of oxidative stress-related diseases, ion channels present changes in their conductive activity, impacting the progression of the disease. A typical oxidative stress-related condition is atherosclerosis, which involves the dysfunction of vascular smooth muscle. We aim to present the state of the art on how redox potential affects vascular smooth muscle ion channel function and summarize if the benefits observed in this disease by using flavonoids involve restoring the ion channel activity. |
| first_indexed | 2024-03-10T10:31:43Z |
| format | Article |
| id | doaj.art-e249b198c0914959a90043538612e344 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:31:43Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e249b198c0914959a90043538612e3442023-11-21T23:39:11ZengMDPI AGMolecules1420-30492021-06-012612355710.3390/molecules26123557Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle ExcitabilityRosa Edith Grijalva-Guiza0Aura Matilde Jiménez-Garduño1Luis Ricardo Hernández2Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, San Andrés Cholula 72810, MexicoDepartamento de Ciencias de la Salud, Universidad de las Américas Puebla, San Andrés Cholula 72810, MexicoDepartamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, San Andrés Cholula 72810, MexicoFlavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be regulated by redox potential, it is expected that during the onset of oxidative stress-related diseases, ion channels present changes in their conductive activity, impacting the progression of the disease. A typical oxidative stress-related condition is atherosclerosis, which involves the dysfunction of vascular smooth muscle. We aim to present the state of the art on how redox potential affects vascular smooth muscle ion channel function and summarize if the benefits observed in this disease by using flavonoids involve restoring the ion channel activity.https://www.mdpi.com/1420-3049/26/12/3557flavonoidsprogressionatherosclerosision channelsvascularsmooth muscle |
| spellingShingle | Rosa Edith Grijalva-Guiza Aura Matilde Jiménez-Garduño Luis Ricardo Hernández Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability Molecules flavonoids progression atherosclerosis ion channels vascular smooth muscle |
| title | Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability |
| title_full | Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability |
| title_fullStr | Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability |
| title_full_unstemmed | Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability |
| title_short | Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability |
| title_sort | potential benefits of flavonoids on the progression of atherosclerosis by their effect on vascular smooth muscle excitability |
| topic | flavonoids progression atherosclerosis ion channels vascular smooth muscle |
| url | https://www.mdpi.com/1420-3049/26/12/3557 |
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