Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review
Adenosquamous carcinoma (ASC) is an aggressive subtype of squamous cell carcinoma (SCC). Due to its poor prognosis, a precise pathological diagnosis of ASC is essential but challenging because its pathological criteria are still unclear. Here, we present a rare case of oral ASC accompanied by acanth...
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| author | Tatsuya Abé Manabu Yamazaki Satoshi Maruyama Nobuyuki Ikeda Yoshimasa Sumita Kei Tomihara Jun-ichi Tanuma |
| author_facet | Tatsuya Abé Manabu Yamazaki Satoshi Maruyama Nobuyuki Ikeda Yoshimasa Sumita Kei Tomihara Jun-ichi Tanuma |
| author_sort | Tatsuya Abé |
| collection | DOAJ |
| description | Adenosquamous carcinoma (ASC) is an aggressive subtype of squamous cell carcinoma (SCC). Due to its poor prognosis, a precise pathological diagnosis of ASC is essential but challenging because its pathological criteria are still unclear. Here, we present a rare case of oral ASC accompanied by acantholytic features. The tumor was raised in the mandibular gingiva and recurred locally approximately 13 months after the initial surgery with cervical lymph node metastasis. Pathological specimens of the primary lesion showed acantholysis in a large area of the SCC. Mucous cells, the characteristic finding indicating glandular differentiation, were imperceptible in the initial surgical specimen but increased in the locally recurrent and metastatic lymph node specimens. In a comprehensive literature review of oral ASC cases, the present case was the only case of ASC with acantholytic features. We reconfirmed that ASC has poor prognoses, such as low 5-year overall survival and disease-free survival, high locoregional recurrence, and high distant metastasis rates. A precise diagnosis of ASC is required for estimating prognosis and undergoing close follow-up, even if the adenocarcinomatous component is limited to a small area in the lesion. |
| first_indexed | 2024-03-09T20:22:45Z |
| format | Article |
| id | doaj.art-e249ff7a6f0745be902723f41fceb479 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:22:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e249ff7a6f0745be902723f41fceb4792023-11-23T23:44:35ZengMDPI AGDiagnostics2075-44182022-10-011210239810.3390/diagnostics12102398Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature ReviewTatsuya Abé0Manabu Yamazaki1Satoshi Maruyama2Nobuyuki Ikeda3Yoshimasa Sumita4Kei Tomihara5Jun-ichi Tanuma6Division of Oral Pathology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanDivision of Oral Pathology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanOral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata 951-8520, JapanOral and Maxillofacial Surgery, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanOral and Maxillofacial Surgery, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanOral and Maxillofacial Surgery, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanDivision of Oral Pathology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, JapanAdenosquamous carcinoma (ASC) is an aggressive subtype of squamous cell carcinoma (SCC). Due to its poor prognosis, a precise pathological diagnosis of ASC is essential but challenging because its pathological criteria are still unclear. Here, we present a rare case of oral ASC accompanied by acantholytic features. The tumor was raised in the mandibular gingiva and recurred locally approximately 13 months after the initial surgery with cervical lymph node metastasis. Pathological specimens of the primary lesion showed acantholysis in a large area of the SCC. Mucous cells, the characteristic finding indicating glandular differentiation, were imperceptible in the initial surgical specimen but increased in the locally recurrent and metastatic lymph node specimens. In a comprehensive literature review of oral ASC cases, the present case was the only case of ASC with acantholytic features. We reconfirmed that ASC has poor prognoses, such as low 5-year overall survival and disease-free survival, high locoregional recurrence, and high distant metastasis rates. A precise diagnosis of ASC is required for estimating prognosis and undergoing close follow-up, even if the adenocarcinomatous component is limited to a small area in the lesion.https://www.mdpi.com/2075-4418/12/10/2398adenosquamous carcinomaacantholytic squamous cell carcinomaoral cavity |
| spellingShingle | Tatsuya Abé Manabu Yamazaki Satoshi Maruyama Nobuyuki Ikeda Yoshimasa Sumita Kei Tomihara Jun-ichi Tanuma Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review Diagnostics adenosquamous carcinoma acantholytic squamous cell carcinoma oral cavity |
| title | Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review |
| title_full | Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review |
| title_fullStr | Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review |
| title_full_unstemmed | Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review |
| title_short | Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review |
| title_sort | adenosquamous carcinoma with the acantholytic feature in the oral cavity a case report and comprehensive literature review |
| topic | adenosquamous carcinoma acantholytic squamous cell carcinoma oral cavity |
| url | https://www.mdpi.com/2075-4418/12/10/2398 |
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