Laboratory aid to the diagnosis and therapy of infection in the neonate
Despite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. For years, investigators have sought a test or panel of tests able to identify septic neonates accurately and rapidly in order to o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-03-01
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| Series: | Pediatric Reports |
| Online Access: | http://www.pagepress.org/journals/index.php/pr/article/view/2198 |
| _version_ | 1818947614802968576 |
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| author | Gaetano Chirico Cristina Loda |
| author_facet | Gaetano Chirico Cristina Loda |
| author_sort | Gaetano Chirico |
| collection | DOAJ |
| description | Despite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. For years, investigators have sought a test or panel of tests able to identify septic neonates accurately and rapidly in order to obtain an early diagnosis and develop a specific effective treatment for a successful outcome. In addition to the standard procedures (blood, CSF, and urine cultures), such panels have included a combination of haematological investigations (total, differential and immature cell counts), and levels of acute-phase reactants (principally CRP and procalcitonin), and cytokines (such as IL-6 or neutrophil CD64). Furthermore, the science of proteomics and genomics has been applied to the search for biomarkers, production of protein profiles and genetic polymorphisms that can rapidly help the prediction, early diagnosis, and treatment of human diseases, but, for now, data are as yet insufficient to confirm their validity. |
| first_indexed | 2024-12-20T08:33:43Z |
| format | Article |
| id | doaj.art-e24bafb886bd440aa9ba15b038e8d99d |
| institution | Directory Open Access Journal |
| issn | 2036-749X 2036-7503 |
| language | English |
| last_indexed | 2024-12-20T08:33:43Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-e24bafb886bd440aa9ba15b038e8d99d2022-12-21T19:46:38ZengMDPI AGPediatric Reports2036-749X2036-75032011-03-0131e1e110.4081/pr.2011.e11410Laboratory aid to the diagnosis and therapy of infection in the neonateGaetano ChiricoCristina LodaDespite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. For years, investigators have sought a test or panel of tests able to identify septic neonates accurately and rapidly in order to obtain an early diagnosis and develop a specific effective treatment for a successful outcome. In addition to the standard procedures (blood, CSF, and urine cultures), such panels have included a combination of haematological investigations (total, differential and immature cell counts), and levels of acute-phase reactants (principally CRP and procalcitonin), and cytokines (such as IL-6 or neutrophil CD64). Furthermore, the science of proteomics and genomics has been applied to the search for biomarkers, production of protein profiles and genetic polymorphisms that can rapidly help the prediction, early diagnosis, and treatment of human diseases, but, for now, data are as yet insufficient to confirm their validity.http://www.pagepress.org/journals/index.php/pr/article/view/2198 |
| spellingShingle | Gaetano Chirico Cristina Loda Laboratory aid to the diagnosis and therapy of infection in the neonate Pediatric Reports |
| title | Laboratory aid to the diagnosis and therapy of infection in the neonate |
| title_full | Laboratory aid to the diagnosis and therapy of infection in the neonate |
| title_fullStr | Laboratory aid to the diagnosis and therapy of infection in the neonate |
| title_full_unstemmed | Laboratory aid to the diagnosis and therapy of infection in the neonate |
| title_short | Laboratory aid to the diagnosis and therapy of infection in the neonate |
| title_sort | laboratory aid to the diagnosis and therapy of infection in the neonate |
| url | http://www.pagepress.org/journals/index.php/pr/article/view/2198 |
| work_keys_str_mv | AT gaetanochirico laboratoryaidtothediagnosisandtherapyofinfectionintheneonate AT cristinaloda laboratoryaidtothediagnosisandtherapyofinfectionintheneonate |