Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis
Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in pat...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.842807/full |
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| author | Shuwen Mu Jun Li Kunzhe Lin Yi Fang Feng Lin Ziqi Li Yongjun Xu Shousen Wang Shousen Wang |
| author_facet | Shuwen Mu Jun Li Kunzhe Lin Yi Fang Feng Lin Ziqi Li Yongjun Xu Shousen Wang Shousen Wang |
| author_sort | Shuwen Mu |
| collection | DOAJ |
| description | Seizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in patients with CVST, this study retrospectively evaluated the clinical data of patients diagnosed with CVST at two centers from January 2011 to December 2020 and analyzed the relationship between admission characteristics and early onset seizures. A total of 112 CVST patients (63 men and 49 women; mean age 39.82 ± 15.70 years) were enrolled in this study, of whom 34 (30.36%) had seizures. For patients with seizures, cerebral hemorrhage, cortical vein thrombosis, anterior superior sagittal sinus (SSS) thrombosis, middle SSS thrombosis, CVST score, modified Rankin Scale, National Institute of Health Stroke Scale (NIHSS) score, neutrophil percentage, and D-dimer level were more severe than those without seizures. Logistic regression analysis showed that cerebral hemorrhage (P = 0.002), anterior SSS thrombosis (P = 0.003), NIHSS score ≥5 (P = 0.003), and D-dimer ≥0.88 mg/L (P = 0.004) were all significant predictive factors of early-onset seizures in CVST patients. Combining the four factors further improved the predictive capability with an area under the curve of 0.871 (95% confidence interval = 0.803–0.939). Further large-scale prospective studies are required to confirm these findings. |
| first_indexed | 2024-04-13T15:45:53Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T15:45:53Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e24cbf45cf59414dafeeebfa7872199d2022-12-22T02:41:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-03-011310.3389/fneur.2022.842807842807Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus ThrombosisShuwen Mu0Jun Li1Kunzhe Lin2Yi Fang3Feng Lin4Ziqi Li5Yongjun Xu6Shousen Wang7Shousen Wang8Department of Neurosurgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, 900th Hospital, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaLaboratory of Basic Medicine, 900th Hospital, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, 900th Hospital, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaSeizures are reported to be important factors contributing to poor prognosis in patients with cerebral venous sinus thrombosis (CVST). However, the predictive factors for concurrent early onset seizures in patients with CVST remain unclear. To identify the predictive factors of early seizures in patients with CVST, this study retrospectively evaluated the clinical data of patients diagnosed with CVST at two centers from January 2011 to December 2020 and analyzed the relationship between admission characteristics and early onset seizures. A total of 112 CVST patients (63 men and 49 women; mean age 39.82 ± 15.70 years) were enrolled in this study, of whom 34 (30.36%) had seizures. For patients with seizures, cerebral hemorrhage, cortical vein thrombosis, anterior superior sagittal sinus (SSS) thrombosis, middle SSS thrombosis, CVST score, modified Rankin Scale, National Institute of Health Stroke Scale (NIHSS) score, neutrophil percentage, and D-dimer level were more severe than those without seizures. Logistic regression analysis showed that cerebral hemorrhage (P = 0.002), anterior SSS thrombosis (P = 0.003), NIHSS score ≥5 (P = 0.003), and D-dimer ≥0.88 mg/L (P = 0.004) were all significant predictive factors of early-onset seizures in CVST patients. Combining the four factors further improved the predictive capability with an area under the curve of 0.871 (95% confidence interval = 0.803–0.939). Further large-scale prospective studies are required to confirm these findings.https://www.frontiersin.org/articles/10.3389/fneur.2022.842807/fullcerebral venous sinus thrombosisseizuresuperior sagittal sinuscerebral hemorrhageNIHSSD-dimer |
| spellingShingle | Shuwen Mu Jun Li Kunzhe Lin Yi Fang Feng Lin Ziqi Li Yongjun Xu Shousen Wang Shousen Wang Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis Frontiers in Neurology cerebral venous sinus thrombosis seizure superior sagittal sinus cerebral hemorrhage NIHSS D-dimer |
| title | Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis |
| title_full | Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis |
| title_fullStr | Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis |
| title_full_unstemmed | Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis |
| title_short | Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis |
| title_sort | predictive factors for early onset seizures in patients with cerebral venous sinus thrombosis |
| topic | cerebral venous sinus thrombosis seizure superior sagittal sinus cerebral hemorrhage NIHSS D-dimer |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.842807/full |
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