Recent advances to combat ESKAPE pathogens with special reference to essential oils
Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1029098/full |
| _version_ | 1811179275978539008 |
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| author | Sujogya Kumar Panda Silvia Buroni Shasank Sekhar Swain Andrea Bonacorsi Erika Alves da Fonseca Amorim Mukta Kulshrestha Luis Cláudio Nascimento da Silva Vishvanath Tiwari |
| author_facet | Sujogya Kumar Panda Silvia Buroni Shasank Sekhar Swain Andrea Bonacorsi Erika Alves da Fonseca Amorim Mukta Kulshrestha Luis Cláudio Nascimento da Silva Vishvanath Tiwari |
| author_sort | Sujogya Kumar Panda |
| collection | DOAJ |
| description | Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics. |
| first_indexed | 2024-04-11T06:33:10Z |
| format | Article |
| id | doaj.art-e24f317c2e8e40e4b94a857c76047fcb |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T06:33:10Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e24f317c2e8e40e4b94a857c76047fcb2022-12-22T04:39:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-12-011310.3389/fmicb.2022.10290981029098Recent advances to combat ESKAPE pathogens with special reference to essential oilsSujogya Kumar Panda0Silvia Buroni1Shasank Sekhar Swain2Andrea Bonacorsi3Erika Alves da Fonseca Amorim4Mukta Kulshrestha5Luis Cláudio Nascimento da Silva6Vishvanath Tiwari7Centre of Environment Studies, Climate Change and Public Health, RUSA 2.0, Utkal University, Vani Vihar, Bhubaneswar, Odisha, IndiaDepartment of Biology and Biotechnology, University of Pavia, Pavia, ItalyDivision of Microbiology and Noncommunicable Diseases (NCDs), Indian Council of Medical Research (ICMR)–Regional Medical Research Centre, Bhubaneswar, Odisha, IndiaDepartment of Biology and Biotechnology, University of Pavia, Pavia, ItalyLaboratory of Microbial Pathogenesis, Universidade Ceuma, São Luís, BrazilDepartment of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, IndiaLaboratory of Microbial Pathogenesis, Universidade Ceuma, São Luís, BrazilDepartment of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, IndiaBiofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1029098/fullantibioticsbiofilmESKAPEessential oilsquorum-sensingsynergy |
| spellingShingle | Sujogya Kumar Panda Silvia Buroni Shasank Sekhar Swain Andrea Bonacorsi Erika Alves da Fonseca Amorim Mukta Kulshrestha Luis Cláudio Nascimento da Silva Vishvanath Tiwari Recent advances to combat ESKAPE pathogens with special reference to essential oils Frontiers in Microbiology antibiotics biofilm ESKAPE essential oils quorum-sensing synergy |
| title | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
| title_full | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
| title_fullStr | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
| title_full_unstemmed | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
| title_short | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
| title_sort | recent advances to combat eskape pathogens with special reference to essential oils |
| topic | antibiotics biofilm ESKAPE essential oils quorum-sensing synergy |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1029098/full |
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