Protein homeostasis in aging and cancer
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can impr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1143532/full |
| _version_ | 1797905012448296960 |
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| author | Xiao-Qiong Chen Tao Shen Shao-Jun Fang Xiao-Min Sun Guo-Yu Li Yun-Feng Li |
| author_facet | Xiao-Qiong Chen Tao Shen Shao-Jun Fang Xiao-Min Sun Guo-Yu Li Yun-Feng Li |
| author_sort | Xiao-Qiong Chen |
| collection | DOAJ |
| description | Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health. |
| first_indexed | 2024-04-10T09:59:23Z |
| format | Article |
| id | doaj.art-e251097c1af04747ba3adb6ef56ad682 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T09:59:23Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e251097c1af04747ba3adb6ef56ad6822023-02-16T11:43:46ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.11435321143532Protein homeostasis in aging and cancerXiao-Qiong ChenTao ShenShao-Jun FangXiao-Min SunGuo-Yu LiYun-Feng LiAging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health.https://www.frontiersin.org/articles/10.3389/fcell.2023.1143532/fullprotein homeostasismolecular chaperonesubiquitin-proteasome systemautophagy-lysosomal systemagingcancer |
| spellingShingle | Xiao-Qiong Chen Tao Shen Shao-Jun Fang Xiao-Min Sun Guo-Yu Li Yun-Feng Li Protein homeostasis in aging and cancer Frontiers in Cell and Developmental Biology protein homeostasis molecular chaperones ubiquitin-proteasome system autophagy-lysosomal system aging cancer |
| title | Protein homeostasis in aging and cancer |
| title_full | Protein homeostasis in aging and cancer |
| title_fullStr | Protein homeostasis in aging and cancer |
| title_full_unstemmed | Protein homeostasis in aging and cancer |
| title_short | Protein homeostasis in aging and cancer |
| title_sort | protein homeostasis in aging and cancer |
| topic | protein homeostasis molecular chaperones ubiquitin-proteasome system autophagy-lysosomal system aging cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1143532/full |
| work_keys_str_mv | AT xiaoqiongchen proteinhomeostasisinagingandcancer AT taoshen proteinhomeostasisinagingandcancer AT shaojunfang proteinhomeostasisinagingandcancer AT xiaominsun proteinhomeostasisinagingandcancer AT guoyuli proteinhomeostasisinagingandcancer AT yunfengli proteinhomeostasisinagingandcancer |