Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study
Background: Triglyceride-glucose (TyG) index has been proposed as a reliable indicator for insulin resistance and proved to be closely associated with the severity and mortality risk of infectious diseases. It remains indistinct whether TyG index performs an important role in predicting in-hospital...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.768101/full |
| _version_ | 1819000102109315072 |
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| author | Tingyu Zhang Yuanni Liu Ziruo Ge Di Tian Ling Lin Zhenghua Zhao Yi Shen Xiaoli Yu Yang Feng Chunqian Qiang Jianping Duan Yanli Ma Tianli Fan Yongxiang Zhao Zhihai Chen |
| author_facet | Tingyu Zhang Yuanni Liu Ziruo Ge Di Tian Ling Lin Zhenghua Zhao Yi Shen Xiaoli Yu Yang Feng Chunqian Qiang Jianping Duan Yanli Ma Tianli Fan Yongxiang Zhao Zhihai Chen |
| author_sort | Tingyu Zhang |
| collection | DOAJ |
| description | Background: Triglyceride-glucose (TyG) index has been proposed as a reliable indicator for insulin resistance and proved to be closely associated with the severity and mortality risk of infectious diseases. It remains indistinct whether TyG index performs an important role in predicting in-hospital mortality in patients with severe fever with thrombocytopenia syndrome (SFTS).Methods: The current study retrospectively recruited patients who were admitted for SFTS from January to December 2019 at five medical centers. TyG index was calculated in accordance with the description of previous study: Ln [fasting triglyceride (TG) (mg/dl) × fasting blood glucose (FBG) (mg/dl)/2]. The observational endpoint of the present study was defined as the in-hospital death.Results: In total, 79 patients (64.9 ± 10.5 years, 39.2% female) who met the enrollment criteria were enrolled in the current study. During the hospitalization period, 17 (21.5%) patients died in the hospital. TyG index remained a significant and independent predictor for in-hospital death despite being fully adjusted for confounders, either being taken as a nominal [hazard ratio (HR) 5.923, 95% CI 1.208–29.036, P = 0.028] or continuous (HR 7.309, 95% CI 1.854–28.818, P = 0.004) variate. TyG index exhibited a moderate-to-high strength in predicting in-hospital death, with an area under the receiver operating characteristic curve (AUC) of 0.821 (95% CI 0.712–0.929, P < 0.001). The addition of TyG index displayed significant enhancement on the predictive value for in-hospital death beyond a baseline model, manifested as increased AUC (baseline model: 0.788, 95% CI 0.676–0.901 vs. + TyG index 0.866, 95% CI 0.783–0.950, P for comparison = 0.041), increased Harrell's C-index (baseline model: 0.762, 95% CI 0.645–0.880 vs. + TyG index 0.813, 95% CI 0.724–0.903, P for comparison = 0.035), significant continuous net reclassification improvement (NRI) (0.310, 95% CI 0.092–0.714, P = 0.013), and significant integrated discrimination improvement (0.111, 95% CI 0.008–0.254, P = 0.040).Conclusion: Triglyceride-glucose index, a novel indicator simply calculated from fasting TG and FBG, is strongly and independently associated with the risk of in-hospital death in patients with SFTS. |
| first_indexed | 2024-12-20T22:27:58Z |
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| last_indexed | 2024-12-20T22:27:58Z |
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| spelling | doaj.art-e251acb7619642199c43b4480228183a2022-12-21T19:24:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.768101768101Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational StudyTingyu Zhang0Yuanni Liu1Ziruo Ge2Di Tian3Ling Lin4Zhenghua Zhao5Yi Shen6Xiaoli Yu7Yang Feng8Chunqian Qiang9Jianping Duan10Yanli Ma11Tianli Fan12Yongxiang Zhao13Zhihai Chen14Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Diseases, Yantai City Hospital for Infectious Disease, Yantai, ChinaDepartment of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Diseases, Yantai City Hospital for Infectious Disease, Yantai, ChinaDepartment of Infectious Diseases, Tai'an City Central Hospital, Tai'an, ChinaDepartment of Infectious Diseases, Dandong Infectious Disease Hospital, Dandong, ChinaDepartment of Infectious Diseases, Dandong Infectious Disease Hospital, Dandong, ChinaDepartment of Infectious Diseases, Tai'an City Central Hospital, Tai'an, ChinaDepartment of Infectious Diseases, Yantai City Hospital for Infectious Disease, Yantai, ChinaDepartment of Infectious Diseases, Qing Dao No. 6 People's Hospital, Qingdao, ChinaDepartment of Infectious Diseases, Qing Dao No. 6 People's Hospital, Qingdao, ChinaDepartment of Infectious Diseases, Qing Dao No. 6 People's Hospital, Qingdao, ChinaDepartment of Infectious Diseases, Dandong Infectious Disease Hospital, Dandong, ChinaDepartment of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaBackground: Triglyceride-glucose (TyG) index has been proposed as a reliable indicator for insulin resistance and proved to be closely associated with the severity and mortality risk of infectious diseases. It remains indistinct whether TyG index performs an important role in predicting in-hospital mortality in patients with severe fever with thrombocytopenia syndrome (SFTS).Methods: The current study retrospectively recruited patients who were admitted for SFTS from January to December 2019 at five medical centers. TyG index was calculated in accordance with the description of previous study: Ln [fasting triglyceride (TG) (mg/dl) × fasting blood glucose (FBG) (mg/dl)/2]. The observational endpoint of the present study was defined as the in-hospital death.Results: In total, 79 patients (64.9 ± 10.5 years, 39.2% female) who met the enrollment criteria were enrolled in the current study. During the hospitalization period, 17 (21.5%) patients died in the hospital. TyG index remained a significant and independent predictor for in-hospital death despite being fully adjusted for confounders, either being taken as a nominal [hazard ratio (HR) 5.923, 95% CI 1.208–29.036, P = 0.028] or continuous (HR 7.309, 95% CI 1.854–28.818, P = 0.004) variate. TyG index exhibited a moderate-to-high strength in predicting in-hospital death, with an area under the receiver operating characteristic curve (AUC) of 0.821 (95% CI 0.712–0.929, P < 0.001). The addition of TyG index displayed significant enhancement on the predictive value for in-hospital death beyond a baseline model, manifested as increased AUC (baseline model: 0.788, 95% CI 0.676–0.901 vs. + TyG index 0.866, 95% CI 0.783–0.950, P for comparison = 0.041), increased Harrell's C-index (baseline model: 0.762, 95% CI 0.645–0.880 vs. + TyG index 0.813, 95% CI 0.724–0.903, P for comparison = 0.035), significant continuous net reclassification improvement (NRI) (0.310, 95% CI 0.092–0.714, P = 0.013), and significant integrated discrimination improvement (0.111, 95% CI 0.008–0.254, P = 0.040).Conclusion: Triglyceride-glucose index, a novel indicator simply calculated from fasting TG and FBG, is strongly and independently associated with the risk of in-hospital death in patients with SFTS.https://www.frontiersin.org/articles/10.3389/fmed.2021.768101/fullsevere fever with thrombocytopenia syndrometriglyceride-glucose indexin-hospital mortalitytriglyceridefasting blood glucose |
| spellingShingle | Tingyu Zhang Yuanni Liu Ziruo Ge Di Tian Ling Lin Zhenghua Zhao Yi Shen Xiaoli Yu Yang Feng Chunqian Qiang Jianping Duan Yanli Ma Tianli Fan Yongxiang Zhao Zhihai Chen Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study Frontiers in Medicine severe fever with thrombocytopenia syndrome triglyceride-glucose index in-hospital mortality triglyceride fasting blood glucose |
| title | Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study |
| title_full | Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study |
| title_fullStr | Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study |
| title_full_unstemmed | Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study |
| title_short | Predictive Value of Triglyceride-Glucose Index for In-hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study |
| title_sort | predictive value of triglyceride glucose index for in hospital mortality in patients with severe fever with thrombocytopenia syndrome a multi center observational study |
| topic | severe fever with thrombocytopenia syndrome triglyceride-glucose index in-hospital mortality triglyceride fasting blood glucose |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.768101/full |
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