Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation
Carboxymethyl starch (CMS) and carboxymethyl cellulose (CMC) loaded by highly dispersed metal subnanoparticles (MSNPs) showed antibacterial activity against <i>E. coli</i> and <i>B. subtilis</i> strains. Copper and silver were found to act in both cationic and zero-valence fo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/4/439 |
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| author | Farzaneh Noori Meriem Megoura Marc-André Labelle Mircea Alexandru Mateescu Abdelkrim Azzouz |
| author_facet | Farzaneh Noori Meriem Megoura Marc-André Labelle Mircea Alexandru Mateescu Abdelkrim Azzouz |
| author_sort | Farzaneh Noori |
| collection | DOAJ |
| description | Carboxymethyl starch (CMS) and carboxymethyl cellulose (CMC) loaded by highly dispersed metal subnanoparticles (MSNPs) showed antibacterial activity against <i>E. coli</i> and <i>B. subtilis</i> strains. Copper and silver were found to act in both cationic and zero-valence forms. The antibacterial activity depends on the metal species content but only up to a certain level. Silver cation (Ag<sup>+</sup>) showed higher antibacterial activity as compared to Ag<sup>0</sup>, which was, however, more effective than Cu<sup>0</sup>, due to weaker retention. The number of carboxyl groups of the biopolymers was found to govern the material dispersion in aqueous media, the metal retention strength and dispersion in the host-matrices. Cation and metal retention in both biopolymers was found to involve interactions with the oxygen atoms of both hydroxyl and carboxyl groups. There exists a ternary interdependence between the Zeta potential (ZP), pH induced by the biocidal agent and its particle size (PS). This interdependence is a key factor in the exchange processes with the surrounding species, including bacteria. Clay mineral incorporation was found to mitigate material dispersion, due to detrimental competitive clay:polymer interaction. This knowledge advancement opens promising prospects for manufacturing metal-loaded materials for biomedical applications. |
| first_indexed | 2024-03-09T11:16:23Z |
| format | Article |
| id | doaj.art-e252c555cfd94398a76ae433a3d2fdc6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T11:16:23Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e252c555cfd94398a76ae433a3d2fdc62023-12-01T00:31:48ZengMDPI AGAntibiotics2079-63822022-03-0111443910.3390/antibiotics11040439Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle IncorporationFarzaneh Noori0Meriem Megoura1Marc-André Labelle2Mircea Alexandru Mateescu3Abdelkrim Azzouz4Nanoqam, Department of Chemistry, Faculty of Sciences, Université du Québec à Montréal, Montreal, QC H3C 3P8, CanadaNanoqam, Department of Chemistry, Faculty of Sciences, Université du Québec à Montréal, Montreal, QC H3C 3P8, CanadaNanoqam, Department of Chemistry, Faculty of Sciences, Université du Québec à Montréal, Montreal, QC H3C 3P8, CanadaNanoqam, Department of Chemistry, Faculty of Sciences, Université du Québec à Montréal, Montreal, QC H3C 3P8, CanadaNanoqam, Department of Chemistry, Faculty of Sciences, Université du Québec à Montréal, Montreal, QC H3C 3P8, CanadaCarboxymethyl starch (CMS) and carboxymethyl cellulose (CMC) loaded by highly dispersed metal subnanoparticles (MSNPs) showed antibacterial activity against <i>E. coli</i> and <i>B. subtilis</i> strains. Copper and silver were found to act in both cationic and zero-valence forms. The antibacterial activity depends on the metal species content but only up to a certain level. Silver cation (Ag<sup>+</sup>) showed higher antibacterial activity as compared to Ag<sup>0</sup>, which was, however, more effective than Cu<sup>0</sup>, due to weaker retention. The number of carboxyl groups of the biopolymers was found to govern the material dispersion in aqueous media, the metal retention strength and dispersion in the host-matrices. Cation and metal retention in both biopolymers was found to involve interactions with the oxygen atoms of both hydroxyl and carboxyl groups. There exists a ternary interdependence between the Zeta potential (ZP), pH induced by the biocidal agent and its particle size (PS). This interdependence is a key factor in the exchange processes with the surrounding species, including bacteria. Clay mineral incorporation was found to mitigate material dispersion, due to detrimental competitive clay:polymer interaction. This knowledge advancement opens promising prospects for manufacturing metal-loaded materials for biomedical applications.https://www.mdpi.com/2079-6382/11/4/439carboxymethyl starchcarboxymethyl cellulosemetal subnanoparticlesantibacterial activity |
| spellingShingle | Farzaneh Noori Meriem Megoura Marc-André Labelle Mircea Alexandru Mateescu Abdelkrim Azzouz Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation Antibiotics carboxymethyl starch carboxymethyl cellulose metal subnanoparticles antibacterial activity |
| title | Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation |
| title_full | Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation |
| title_fullStr | Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation |
| title_full_unstemmed | Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation |
| title_short | Synthesis of Metal-Loaded Carboxylated Biopolymers with Antibacterial Activity through Metal Subnanoparticle Incorporation |
| title_sort | synthesis of metal loaded carboxylated biopolymers with antibacterial activity through metal subnanoparticle incorporation |
| topic | carboxymethyl starch carboxymethyl cellulose metal subnanoparticles antibacterial activity |
| url | https://www.mdpi.com/2079-6382/11/4/439 |
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