Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle
The genus capripoxvirus consists of sheeppox virus, goatpox virus, and lumpy skin disease virus, which affect sheep, goats, and cattle, respectively. Together capripoxviruses cause significant economic losses to the sheep, goat, and cattle industry where these diseases are present. These diseases ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2019.00450/full |
| _version_ | 1818499073203765248 |
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| author | Mahder Teffera Mahder Teffera Shawn Babiuk Shawn Babiuk |
| author_facet | Mahder Teffera Mahder Teffera Shawn Babiuk Shawn Babiuk |
| author_sort | Mahder Teffera |
| collection | DOAJ |
| description | The genus capripoxvirus consists of sheeppox virus, goatpox virus, and lumpy skin disease virus, which affect sheep, goats, and cattle, respectively. Together capripoxviruses cause significant economic losses to the sheep, goat, and cattle industry where these diseases are present. These diseases have spread into previously free bordering regions most recently demonstrated with the spread of lumpy skin disease virus into the Middle East, some Eastern European countries, and Russia. This recent spread has highlighted the transboundary nature of these diseases. To control lumpy skin disease virus, live attenuated viral vaccines are used in endemic countries as well as in response to an outbreak. For sheeppox and goatpox, live attenuated viral vaccines are used in endemic countries; these diseases can also be contained through slaughter of infected animals to stamp out the disease. The thermostability, narrow host range, and ability of capripoxviruses to express a wide variety of antigens make capripoxviruses ideal vectors. The ability to immunize animals against multiple diseases simultaneously increases vaccination efficiency by decreasing the number of vaccinations required. Additionally, the use of capripoxvirus vectored vaccines allows the possibility of differentiating infected from vaccinated animals. Arboviruses such as bluetongue virus and Rift Valley fever viruses are also responsible for significant economic losses in endemic countries. In the case of Rift Valley fever virus, vaccination is not routinely practiced unless there is an outbreak making vaccination not as effective, therefore, incorporating Rift Valley fever vaccination into routine capripoxvirus vaccination would be highly beneficial. This review will discuss the potential of using capripoxvirus as a vector expressing protective arboviral antigens. |
| first_indexed | 2024-12-10T20:24:17Z |
| format | Article |
| id | doaj.art-e253b3c32312488bb4bf49363a40200a |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-10T20:24:17Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-e253b3c32312488bb4bf49363a40200a2022-12-22T01:34:55ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692019-12-01610.3389/fvets.2019.00450501910Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and CattleMahder Teffera0Mahder Teffera1Shawn Babiuk2Shawn Babiuk3Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, CanadaDepartment of Immunology, University of Manitoba, Winnipeg, MB, CanadaCanadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB, CanadaDepartment of Immunology, University of Manitoba, Winnipeg, MB, CanadaThe genus capripoxvirus consists of sheeppox virus, goatpox virus, and lumpy skin disease virus, which affect sheep, goats, and cattle, respectively. Together capripoxviruses cause significant economic losses to the sheep, goat, and cattle industry where these diseases are present. These diseases have spread into previously free bordering regions most recently demonstrated with the spread of lumpy skin disease virus into the Middle East, some Eastern European countries, and Russia. This recent spread has highlighted the transboundary nature of these diseases. To control lumpy skin disease virus, live attenuated viral vaccines are used in endemic countries as well as in response to an outbreak. For sheeppox and goatpox, live attenuated viral vaccines are used in endemic countries; these diseases can also be contained through slaughter of infected animals to stamp out the disease. The thermostability, narrow host range, and ability of capripoxviruses to express a wide variety of antigens make capripoxviruses ideal vectors. The ability to immunize animals against multiple diseases simultaneously increases vaccination efficiency by decreasing the number of vaccinations required. Additionally, the use of capripoxvirus vectored vaccines allows the possibility of differentiating infected from vaccinated animals. Arboviruses such as bluetongue virus and Rift Valley fever viruses are also responsible for significant economic losses in endemic countries. In the case of Rift Valley fever virus, vaccination is not routinely practiced unless there is an outbreak making vaccination not as effective, therefore, incorporating Rift Valley fever vaccination into routine capripoxvirus vaccination would be highly beneficial. This review will discuss the potential of using capripoxvirus as a vector expressing protective arboviral antigens.https://www.frontiersin.org/article/10.3389/fvets.2019.00450/fullcapripoxvirusesRift Valley feverbluetonguevaccinearbovirusesvector |
| spellingShingle | Mahder Teffera Mahder Teffera Shawn Babiuk Shawn Babiuk Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle Frontiers in Veterinary Science capripoxviruses Rift Valley fever bluetongue vaccine arboviruses vector |
| title | Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle |
| title_full | Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle |
| title_fullStr | Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle |
| title_full_unstemmed | Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle |
| title_short | Potential of Using Capripoxvirus Vectored Vaccines Against Arboviruses in Sheep, Goats, and Cattle |
| title_sort | potential of using capripoxvirus vectored vaccines against arboviruses in sheep goats and cattle |
| topic | capripoxviruses Rift Valley fever bluetongue vaccine arboviruses vector |
| url | https://www.frontiersin.org/article/10.3389/fvets.2019.00450/full |
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