Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology
Abstract Background Methicillin-resistant Staphylococcus aureus poses a threat to elderly living in nursing homes. Studies focusing on the epidemiology of colonization may help in the design of infection control strategies. Objective To identify factors associated with MRSA colonization and the diss...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
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| Online Access: | http://link.springer.com/article/10.1186/s12941-018-0271-z |
| _version_ | 1818493600158187520 |
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| author | Monica da Silveira Maria de Lourdes Ribeiro de Souza da Cunha Camila Sena Martins de Souza Adriana Aparecida Feltrin Correa Carlos Magno Castelo Branco Fortaleza |
| author_facet | Monica da Silveira Maria de Lourdes Ribeiro de Souza da Cunha Camila Sena Martins de Souza Adriana Aparecida Feltrin Correa Carlos Magno Castelo Branco Fortaleza |
| author_sort | Monica da Silveira |
| collection | DOAJ |
| description | Abstract Background Methicillin-resistant Staphylococcus aureus poses a threat to elderly living in nursing homes. Studies focusing on the epidemiology of colonization may help in the design of infection control strategies. Objective To identify factors associated with MRSA colonization and the dissemination of clones among nursing home residents. Methods Nasal swabs were collected from 300 persons from nine nursing homes in the city of Bauru, Brazil. Resistance to methicillin was identified through amplification of the mecA gene. Strain typing (Pulsed-Field Gel Electrophoresis) and characterization of the Staphylococcal Chromosome Cassette (SCC) mec was performed. Univariate and multivariable models were used to identify predictors of overall S. aureus and MRSA carriage. Results Rates of S. aureus and MRSA colonization were 17.7 and 3.7%, respectively. Age and recent admission to a hospital were independently associated with colonization with S. aureus. MRSA colonization was associated with living in small (< 15 residents) and medium-sized (15–49 residents) facilities, as well as with recent hospitalization. Most MRSA strains carried SCCmec types II or IV, and there was evidence of clonal spread within and among different facilities. Conclusions MRSA may be introduced in nursing homes form hospitals or arise from the community setting. Screening for asymptomatic colonization may identify persons with greater risk for infection, and is advised for residents discharged from acute care hospitals. |
| first_indexed | 2024-12-10T17:57:08Z |
| format | Article |
| id | doaj.art-e2540154de1f4285a8513d2d47d0265f |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-10T17:57:08Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-e2540154de1f4285a8513d2d47d0265f2022-12-22T01:38:55ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112018-05-011711510.1186/s12941-018-0271-zNasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiologyMonica da Silveira0Maria de Lourdes Ribeiro de Souza da Cunha1Camila Sena Martins de Souza2Adriana Aparecida Feltrin Correa3Carlos Magno Castelo Branco Fortaleza4Department of Tropical Diseases, Botucatu School of Medicine, University Hospital, UNESP-Univ Estadual PaulistaDepartment of Microbiology and Immunology, Botucatu Biosciences Institute, UNESP-Univ Estadual PaulistaDepartment of Microbiology and Immunology, Botucatu Biosciences Institute, UNESP-Univ Estadual PaulistaDepartment of Tropical Diseases, Botucatu School of Medicine, University Hospital, UNESP-Univ Estadual PaulistaDepartment of Tropical Diseases, Botucatu School of Medicine, University Hospital, UNESP-Univ Estadual PaulistaAbstract Background Methicillin-resistant Staphylococcus aureus poses a threat to elderly living in nursing homes. Studies focusing on the epidemiology of colonization may help in the design of infection control strategies. Objective To identify factors associated with MRSA colonization and the dissemination of clones among nursing home residents. Methods Nasal swabs were collected from 300 persons from nine nursing homes in the city of Bauru, Brazil. Resistance to methicillin was identified through amplification of the mecA gene. Strain typing (Pulsed-Field Gel Electrophoresis) and characterization of the Staphylococcal Chromosome Cassette (SCC) mec was performed. Univariate and multivariable models were used to identify predictors of overall S. aureus and MRSA carriage. Results Rates of S. aureus and MRSA colonization were 17.7 and 3.7%, respectively. Age and recent admission to a hospital were independently associated with colonization with S. aureus. MRSA colonization was associated with living in small (< 15 residents) and medium-sized (15–49 residents) facilities, as well as with recent hospitalization. Most MRSA strains carried SCCmec types II or IV, and there was evidence of clonal spread within and among different facilities. Conclusions MRSA may be introduced in nursing homes form hospitals or arise from the community setting. Screening for asymptomatic colonization may identify persons with greater risk for infection, and is advised for residents discharged from acute care hospitals.http://link.springer.com/article/10.1186/s12941-018-0271-zStaphylococcus aureusMRSANursing homes |
| spellingShingle | Monica da Silveira Maria de Lourdes Ribeiro de Souza da Cunha Camila Sena Martins de Souza Adriana Aparecida Feltrin Correa Carlos Magno Castelo Branco Fortaleza Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology Annals of Clinical Microbiology and Antimicrobials Staphylococcus aureus MRSA Nursing homes |
| title | Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology |
| title_full | Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology |
| title_fullStr | Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology |
| title_full_unstemmed | Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology |
| title_short | Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology |
| title_sort | nasal colonization with methicillin resistant staphylococcus aureus among elderly living in nursing homes in brazil risk factors and molecular epidemiology |
| topic | Staphylococcus aureus MRSA Nursing homes |
| url | http://link.springer.com/article/10.1186/s12941-018-0271-z |
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