Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans
Nanoplastics and microbial pathogens are both widely distributed in the environment; however, their combined toxicity remains largely unclear. Using Caenorhabditis elegans as an animal model, we examined the possible effect of exposure to polystyrene nanoparticle (PS-NP) in Acinetobacter johnsonii A...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323006358 |
| _version_ | 1827866517649227776 |
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| author | Mingfeng Tang Guoying Ding Liane Li Guosheng Xiao Dayong Wang |
| author_facet | Mingfeng Tang Guoying Ding Liane Li Guosheng Xiao Dayong Wang |
| author_sort | Mingfeng Tang |
| collection | DOAJ |
| description | Nanoplastics and microbial pathogens are both widely distributed in the environment; however, their combined toxicity remains largely unclear. Using Caenorhabditis elegans as an animal model, we examined the possible effect of exposure to polystyrene nanoparticle (PS-NP) in Acinetobacter johnsonii AC15 (a bacterial pathogen) infected animals. Exposure to PS-NP at the concentrations of 0.1–10 μg/L significantly enhanced the toxicity of Acinetobacter johnsonii AC15 infection on lifespan and locomotion behaviors. In addition, after exposure to 0.1–10 μg/L PS-NP, the accumulation of Acinetobacter johnsonii AC15 in body of nematodes was also increased. Meanwhile, the innate immune response indicated by the increase of antimicrobial gene expressions in Acinetobacter johnsonii AC15 infected nematodes was suppressed by exposure to 0.1–10 μg/L PS-NP. Moreover, expressions of egl-1, dbl-1, bar-1, daf-16, pmk-1, and elt-2 governing the bacterial infection and immunity in Acinetobacter johnsonii AC15 infected nematodes were further inhibited by exposure to 0.1–10 μg/L PS-NP. Therefore, our data suggested the possible exposure risk of nanoplastic at predicted environmental concentrations in enhancing the toxic effects of bacterial pathogens on environmental organisms. |
| first_indexed | 2024-03-12T15:05:49Z |
| format | Article |
| id | doaj.art-e25430dd48934fb88c1cc452246f7497 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:49Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-e25430dd48934fb88c1cc452246f74972023-08-13T04:51:42ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115131Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegansMingfeng Tang0Guoying Ding1Liane Li2Guosheng Xiao3Dayong Wang4College of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, ChinaCollege of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, ChinaCollege of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, ChinaCollege of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, China; Corresponding author.College of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, China; Medical School, Southeast University, Nanjing, China; Corresponding author at: College of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, China.Nanoplastics and microbial pathogens are both widely distributed in the environment; however, their combined toxicity remains largely unclear. Using Caenorhabditis elegans as an animal model, we examined the possible effect of exposure to polystyrene nanoparticle (PS-NP) in Acinetobacter johnsonii AC15 (a bacterial pathogen) infected animals. Exposure to PS-NP at the concentrations of 0.1–10 μg/L significantly enhanced the toxicity of Acinetobacter johnsonii AC15 infection on lifespan and locomotion behaviors. In addition, after exposure to 0.1–10 μg/L PS-NP, the accumulation of Acinetobacter johnsonii AC15 in body of nematodes was also increased. Meanwhile, the innate immune response indicated by the increase of antimicrobial gene expressions in Acinetobacter johnsonii AC15 infected nematodes was suppressed by exposure to 0.1–10 μg/L PS-NP. Moreover, expressions of egl-1, dbl-1, bar-1, daf-16, pmk-1, and elt-2 governing the bacterial infection and immunity in Acinetobacter johnsonii AC15 infected nematodes were further inhibited by exposure to 0.1–10 μg/L PS-NP. Therefore, our data suggested the possible exposure risk of nanoplastic at predicted environmental concentrations in enhancing the toxic effects of bacterial pathogens on environmental organisms.http://www.sciencedirect.com/science/article/pii/S0147651323006358C. elegansCombinational exposureNanoplasticBacterial infection |
| spellingShingle | Mingfeng Tang Guoying Ding Liane Li Guosheng Xiao Dayong Wang Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans Ecotoxicology and Environmental Safety C. elegans Combinational exposure Nanoplastic Bacterial infection |
| title | Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans |
| title_full | Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans |
| title_fullStr | Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans |
| title_full_unstemmed | Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans |
| title_short | Exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of Acinetobacter johnsonii AC15 infection on Caenorhabditis elegans |
| title_sort | exposure to polystyrene nanoparticles at predicted environmental concentrations enhances toxic effects of acinetobacter johnsonii ac15 infection on caenorhabditis elegans |
| topic | C. elegans Combinational exposure Nanoplastic Bacterial infection |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323006358 |
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