Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
Abstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent...
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| Format: | Article |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01454-5 |
| _version_ | 1819006336071892992 |
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| author | Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura |
| author_facet | Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura |
| author_sort | Hirotake Takahashi |
| collection | DOAJ |
| description | Abstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P < 0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P < 0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = −0.125, P = 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = −0.198, P = 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics. |
| first_indexed | 2024-12-21T00:07:04Z |
| format | Article |
| id | doaj.art-e254922173444f8ebb477b4401e1a665 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T00:07:04Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-e254922173444f8ebb477b4401e1a6652022-12-21T19:22:26ZengNature PortfolioScientific Reports2045-23222021-11-0111111010.1038/s41598-021-01454-5Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failureHirotake Takahashi0Yusuke Kashiwagi1Tomohisa Nagoshi2Yoshiro Tanaka3Yuhei Oi4Haruka Kimura5Kousuke Minai6Michihiro Yoshimura7Division of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineDivision of Cardiology, Department of Internal Medicine, The Jikei University School of MedicineAbstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P < 0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P < 0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = −0.125, P = 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = −0.198, P = 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.https://doi.org/10.1038/s41598-021-01454-5 |
| spellingShingle | Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure Scientific Reports |
| title | Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure |
| title_full | Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure |
| title_fullStr | Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure |
| title_full_unstemmed | Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure |
| title_short | Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure |
| title_sort | low triiodothyronine levels correlate with high b type natriuretic peptide levels in patients with heart failure |
| url | https://doi.org/10.1038/s41598-021-01454-5 |
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