Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature
Abstract Background We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-021-00600-y |
| _version_ | 1818986780448260096 |
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| author | Debendra Pattanaik Shaunah Ritter Joseph Fahhoum |
| author_facet | Debendra Pattanaik Shaunah Ritter Joseph Fahhoum |
| author_sort | Debendra Pattanaik |
| collection | DOAJ |
| description | Abstract Background We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19 infection with common variable immunodeficiency (CVID) and GLILD is not well known. Case presentation Our patient met the clinical features of CVID secondary to low IgG/IgA, recurrent infections, and failure to respond to pneumococcal vaccination. He was treated with monthly maintenance IVIG therapy. Our patient also was diagnosed with co-existing GLILD that despite IVIG treatment was progressing. The patient needed to be started on Rituxan and Mycophenolate mofetil to achieve control but unfortunately became infected with COVID19 delaying his treatment for GLILD. Our patient only suffered from mild COVID 19 infection and was able to make antibodies to this. We believe severe infection was avoided as his CVID was well controlled with IVIG therapy despite progression of his granulomatous interstitial lung disease. Conclusion In conclusion, our patient with CVID with co-existing biopsy proven granulomatous interstitial lung disease despite being very high risk for severe COVID 19 infections only had mild infection. This was believed to be due to well controlled CVID with IVIG therapy. |
| first_indexed | 2024-12-20T18:56:14Z |
| format | Article |
| id | doaj.art-e2567afb57954b09a9513e80578c49a4 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-20T18:56:14Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-e2567afb57954b09a9513e80578c49a42022-12-21T19:29:31ZengBMCAllergy, Asthma & Clinical Immunology1710-14922021-09-011711610.1186/s13223-021-00600-yCommon variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literatureDebendra Pattanaik0Shaunah Ritter1Joseph Fahhoum2Division of Rheumatology and Immunology, Department of Medicine, University of Tennessee Health Sciences CenterDivision of Allergy and Clinical Immunology, Le Bonheur Children’s Hospital, University of Tennessee Health Sciences CenterDivision of Allergy and Clinical Immunology, Le Bonheur Children’s Hospital, University of Tennessee Health Sciences CenterAbstract Background We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19 infection with common variable immunodeficiency (CVID) and GLILD is not well known. Case presentation Our patient met the clinical features of CVID secondary to low IgG/IgA, recurrent infections, and failure to respond to pneumococcal vaccination. He was treated with monthly maintenance IVIG therapy. Our patient also was diagnosed with co-existing GLILD that despite IVIG treatment was progressing. The patient needed to be started on Rituxan and Mycophenolate mofetil to achieve control but unfortunately became infected with COVID19 delaying his treatment for GLILD. Our patient only suffered from mild COVID 19 infection and was able to make antibodies to this. We believe severe infection was avoided as his CVID was well controlled with IVIG therapy despite progression of his granulomatous interstitial lung disease. Conclusion In conclusion, our patient with CVID with co-existing biopsy proven granulomatous interstitial lung disease despite being very high risk for severe COVID 19 infections only had mild infection. This was believed to be due to well controlled CVID with IVIG therapy.https://doi.org/10.1186/s13223-021-00600-yCVIDGLILDCOVID-19 |
| spellingShingle | Debendra Pattanaik Shaunah Ritter Joseph Fahhoum Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature Allergy, Asthma & Clinical Immunology CVID GLILD COVID-19 |
| title | Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature |
| title_full | Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature |
| title_fullStr | Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature |
| title_full_unstemmed | Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature |
| title_short | Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature |
| title_sort | common variable immunodeficiency cvid with granulomatous interstitial lung disease glild and sars covid 19 infection case report and review of literature |
| topic | CVID GLILD COVID-19 |
| url | https://doi.org/10.1186/s13223-021-00600-y |
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