Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

Tumors that lack T cell infiltration are less likely to respond to immune checkpoint inhibition and could benefit from cancer vaccination for the initiation of anti-tumor T cell responses. An attractive vaccine strategy is in vivo targeting of dendritic cells (DCs), key initiators of antigen-specifi...

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Bibliographic Details
Main Authors: Sophie K. Horrevorts, Dorian A. Stolk, Rieneke van de Ven, Myrthe Hulst, Bert van Het Hof, Sanne Duinkerken, Marieke H. Heineke, Wenbin Ma, Sophie A. Dusoswa, Rienk Nieuwland, Juan J. Garcia-Vallejo, Arjan A. van de Loosdrecht, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
dendritic cell
apoptotic extracellular vesicles
T cell priming
cancer vaccine
glycan modification
C-type lectin
Online Access:https://www.mdpi.com/2072-6694/11/9/1266

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