Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of my...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2019-07-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2019.1643220 |
| _version_ | 1797971520515997696 |
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| author | Jason L. Chien Valentina Baez Harshad R. Mody |
| author_facet | Jason L. Chien Valentina Baez Harshad R. Mody |
| author_sort | Jason L. Chien |
| collection | DOAJ |
| description | Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of myasthenia gravis exacerbation associated with gabapentin in the literature. We present a patient with uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use and provide a review for the three published cases. |
| first_indexed | 2024-04-11T03:33:55Z |
| format | Article |
| id | doaj.art-e259c62e44494229843407bae12a8347 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:33:55Z |
| publishDate | 2019-07-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-e259c62e44494229843407bae12a83472023-01-02T05:57:37ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662019-07-019437137210.1080/20009666.2019.16432201643220Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin useJason L. Chien0Valentina Baez1Harshad R. Mody2Medstar Harbor HospitalMedstar Harbor HospitalMedstar Harbor HospitalGabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of myasthenia gravis exacerbation associated with gabapentin in the literature. We present a patient with uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use and provide a review for the three published cases.http://dx.doi.org/10.1080/20009666.2019.1643220Gabapentinmyasthenia gravis |
| spellingShingle | Jason L. Chien Valentina Baez Harshad R. Mody Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use Journal of Community Hospital Internal Medicine Perspectives Gabapentin myasthenia gravis |
| title | Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| title_full | Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| title_fullStr | Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| title_full_unstemmed | Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| title_short | Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| title_sort | uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use |
| topic | Gabapentin myasthenia gravis |
| url | http://dx.doi.org/10.1080/20009666.2019.1643220 |
| work_keys_str_mv | AT jasonlchien uncontrolledrecurrentmyastheniagravisexacerbationssecondarytochronicgabapentinuse AT valentinabaez uncontrolledrecurrentmyastheniagravisexacerbationssecondarytochronicgabapentinuse AT harshadrmody uncontrolledrecurrentmyastheniagravisexacerbationssecondarytochronicgabapentinuse |