Dietary fiber intake and risk of gallstone: a case–control study
Abstract Background Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associations between dietary factors and risk of disease. The present study aimed to inve...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02752-0 |
| _version_ | 1797845978856816640 |
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| author | Asal Neshatbini Tehrani Saeede Saadati Zahra Yari Amin Salehpour Amir Sadeghi Ghazal Daftari Moloud Ghorbani Azita Hekmatdoost |
| author_facet | Asal Neshatbini Tehrani Saeede Saadati Zahra Yari Amin Salehpour Amir Sadeghi Ghazal Daftari Moloud Ghorbani Azita Hekmatdoost |
| author_sort | Asal Neshatbini Tehrani |
| collection | DOAJ |
| description | Abstract Background Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associations between dietary factors and risk of disease. The present study aimed to investigate the potential associations between dietary fibers with the risk of gallstone disease. Methods In this case–control study, 189 GSD patients with less than one month of diagnosis and 342 age‑matched controls were enrolled. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models. Results Comparing the highest versus the lowest tertile, significant reverse associations were observed between odds of GSD and each category of dietary fiber intake including total (OR T3 vs. T1 = 0.44, 95% CI: 0.37–0.7, P for trend = 0.015), soluble (OR T3 vs. T1 = 0.51, 95% CI: 0.3–0.8, P for trend = 0.048) and insoluble (OR T3 vs. T1 = 0.56, 95% CI: 0.3–0.9, P for trend < 0.001). The relationship between dietary fiber intake and the risk of gallstones was more prominent in overweight and obese subjects than in subjects with a normal body mass index. Conclusion Comprehensive assessment of the associations of dietary fiber intake with GSD showed that higher intakes of dietary fiber were significantly associated with reduced GSD risk. |
| first_indexed | 2024-04-09T17:47:41Z |
| format | Article |
| id | doaj.art-e25bca97b6c34dbb8ac1803599de1fee |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-09T17:47:41Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-e25bca97b6c34dbb8ac1803599de1fee2023-04-16T11:16:03ZengBMCBMC Gastroenterology1471-230X2023-04-012311810.1186/s12876-023-02752-0Dietary fiber intake and risk of gallstone: a case–control studyAsal Neshatbini Tehrani0Saeede Saadati1Zahra Yari2Amin Salehpour3Amir Sadeghi4Ghazal Daftari5Moloud Ghorbani6Azita Hekmatdoost7Student Research Committee, Ahvaz Jundishapur University of Medical SciencesDepartment of Medicine, School of Clinical Sciences, Monash UniversityDepartment of Nutrition Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences TehranSchool of Public Health, Occupational Health Research Center, Iran Universityof Medical SciencesResearch Institute for Gastroenterology and Liver Diseases of Taleghani Hospital, Shahid Beheshti University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesDepartment of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical SciencesClinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences TehranAbstract Background Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associations between dietary factors and risk of disease. The present study aimed to investigate the potential associations between dietary fibers with the risk of gallstone disease. Methods In this case–control study, 189 GSD patients with less than one month of diagnosis and 342 age‑matched controls were enrolled. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models. Results Comparing the highest versus the lowest tertile, significant reverse associations were observed between odds of GSD and each category of dietary fiber intake including total (OR T3 vs. T1 = 0.44, 95% CI: 0.37–0.7, P for trend = 0.015), soluble (OR T3 vs. T1 = 0.51, 95% CI: 0.3–0.8, P for trend = 0.048) and insoluble (OR T3 vs. T1 = 0.56, 95% CI: 0.3–0.9, P for trend < 0.001). The relationship between dietary fiber intake and the risk of gallstones was more prominent in overweight and obese subjects than in subjects with a normal body mass index. Conclusion Comprehensive assessment of the associations of dietary fiber intake with GSD showed that higher intakes of dietary fiber were significantly associated with reduced GSD risk.https://doi.org/10.1186/s12876-023-02752-0GallstoneDietary fiberCholelithiasis |
| spellingShingle | Asal Neshatbini Tehrani Saeede Saadati Zahra Yari Amin Salehpour Amir Sadeghi Ghazal Daftari Moloud Ghorbani Azita Hekmatdoost Dietary fiber intake and risk of gallstone: a case–control study BMC Gastroenterology Gallstone Dietary fiber Cholelithiasis |
| title | Dietary fiber intake and risk of gallstone: a case–control study |
| title_full | Dietary fiber intake and risk of gallstone: a case–control study |
| title_fullStr | Dietary fiber intake and risk of gallstone: a case–control study |
| title_full_unstemmed | Dietary fiber intake and risk of gallstone: a case–control study |
| title_short | Dietary fiber intake and risk of gallstone: a case–control study |
| title_sort | dietary fiber intake and risk of gallstone a case control study |
| topic | Gallstone Dietary fiber Cholelithiasis |
| url | https://doi.org/10.1186/s12876-023-02752-0 |
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