Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report
Abstract Background The clinical manifestation following methanol toxicity accounts for a life-threatening problem that contributes to metabolic disorders, neurological complications, blindness, and even death. There is no completely effective treatment to retain the patient’s vision. Herein, we app...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-03899-w |
| _version_ | 1797841041666080768 |
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| author | Fatemeh Vafapour Sajad Jahangiri-Mehr Sajad Hassanzadeh |
| author_facet | Fatemeh Vafapour Sajad Jahangiri-Mehr Sajad Hassanzadeh |
| author_sort | Fatemeh Vafapour |
| collection | DOAJ |
| description | Abstract Background The clinical manifestation following methanol toxicity accounts for a life-threatening problem that contributes to metabolic disorders, neurological complications, blindness, and even death. There is no completely effective treatment to retain the patient’s vision. Herein, we apply a new therapeutic strategy for the recovery of bilateral blindness in a patient who had ingested methanol. Case presentation A 27-year-old Iranian man with complete bilateral blindness was referred 3 days after accidental ingestion of methanol to the poisoning center at Jalil Hospital, Yasuj, Iran, in 2022. After taking his medical history, performing neurologic and ophthalmologic examinations, and routine laboratory tests, ordinary management was undertaken and counterpoisons were given for 4–5 days; however, the blindness did not reverse. Following the 4–5 days of unsuccessful standard management, he was given ten doses of subcutaneous erythropoietin 10,000 IU/12 hours twice daily, folinic acid 50 mg/12 hours, and methylprednisolone 250 mg/6 hours for 5 days. After five days, vision of both eyes recovered, reaching 1/10 in the left and 7/10 in the right eye. He remained under daily supervision until his release from the hospital, and he was discharged from the hospital 15 days post admission. In outpatient follow-up, his visual acuity was improved without having any side effects at 2 weeks after discharge. Conclusion A combination of erythropoietin and a high dose of methylprednisolone were useful for relieving the critical optic neuropathy and improved the optical neurological disorder following methanol toxicity. |
| first_indexed | 2024-04-09T16:24:32Z |
| format | Article |
| id | doaj.art-e25ccd61362343249386e73c75de1729 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-09T16:24:32Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-e25ccd61362343249386e73c75de17292023-04-23T11:18:27ZengBMCJournal of Medical Case Reports1752-19472023-04-011711510.1186/s13256-023-03899-wDelayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case reportFatemeh Vafapour0Sajad Jahangiri-Mehr1Sajad Hassanzadeh2Department of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesDepartment of Ophtalmology, School of Medicine, Yasuj University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesAbstract Background The clinical manifestation following methanol toxicity accounts for a life-threatening problem that contributes to metabolic disorders, neurological complications, blindness, and even death. There is no completely effective treatment to retain the patient’s vision. Herein, we apply a new therapeutic strategy for the recovery of bilateral blindness in a patient who had ingested methanol. Case presentation A 27-year-old Iranian man with complete bilateral blindness was referred 3 days after accidental ingestion of methanol to the poisoning center at Jalil Hospital, Yasuj, Iran, in 2022. After taking his medical history, performing neurologic and ophthalmologic examinations, and routine laboratory tests, ordinary management was undertaken and counterpoisons were given for 4–5 days; however, the blindness did not reverse. Following the 4–5 days of unsuccessful standard management, he was given ten doses of subcutaneous erythropoietin 10,000 IU/12 hours twice daily, folinic acid 50 mg/12 hours, and methylprednisolone 250 mg/6 hours for 5 days. After five days, vision of both eyes recovered, reaching 1/10 in the left and 7/10 in the right eye. He remained under daily supervision until his release from the hospital, and he was discharged from the hospital 15 days post admission. In outpatient follow-up, his visual acuity was improved without having any side effects at 2 weeks after discharge. Conclusion A combination of erythropoietin and a high dose of methylprednisolone were useful for relieving the critical optic neuropathy and improved the optical neurological disorder following methanol toxicity.https://doi.org/10.1186/s13256-023-03899-wMethanol toxicityBlindnessErythropoietin |
| spellingShingle | Fatemeh Vafapour Sajad Jahangiri-Mehr Sajad Hassanzadeh Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report Journal of Medical Case Reports Methanol toxicity Blindness Erythropoietin |
| title | Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report |
| title_full | Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report |
| title_fullStr | Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report |
| title_full_unstemmed | Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report |
| title_short | Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report |
| title_sort | delayed reversal of methanol induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone a case report |
| topic | Methanol toxicity Blindness Erythropoietin |
| url | https://doi.org/10.1186/s13256-023-03899-w |
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