Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases
Vaccines can prevent many millions of illnesses against infectious diseases and save numerous lives every year. However, traditional vaccines such as inactivated viral and live attenuated vaccines cannot adapt to emerging pandemics due to their time-consuming development. With the global outbreak of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896958/full |
| _version_ | 1818195514566377472 |
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| author | Lu Yang Lin Tang Ming Zhang Chaoyong Liu Chaoyong Liu |
| author_facet | Lu Yang Lin Tang Ming Zhang Chaoyong Liu Chaoyong Liu |
| author_sort | Lu Yang |
| collection | DOAJ |
| description | Vaccines can prevent many millions of illnesses against infectious diseases and save numerous lives every year. However, traditional vaccines such as inactivated viral and live attenuated vaccines cannot adapt to emerging pandemics due to their time-consuming development. With the global outbreak of the COVID-19 epidemic, the virus continues to evolve and mutate, producing mutants with enhanced transmissibility and virulence; the rapid development of vaccines against such emerging global pandemics becomes more and more critical. In recent years, mRNA vaccines have been of significant interest in combating emerging infectious diseases due to their rapid development and large-scale production advantages. However, their development still suffers from many hurdles such as their safety, cellular delivery, uptake, and response to their manufacturing, logistics, and storage. More efforts are still required to optimize the molecular designs of mRNA molecules with increased protein expression and enhanced structural stability. In addition, a variety of delivery systems are also needed to achieve effective delivery of vaccines. In this review, we highlight the advances in mRNA vaccines against various infectious diseases and discuss the molecular design principles and delivery systems of associated mRNA vaccines. The current state of the clinical application of mRNA vaccine pipelines against various infectious diseases and the challenge, safety, and protective effect of associated vaccines are also discussed. |
| first_indexed | 2024-12-12T01:19:24Z |
| format | Article |
| id | doaj.art-e25cda3a4e4a4243a452cfb296c808c3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T01:19:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e25cda3a4e4a4243a452cfb296c808c32022-12-22T00:43:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.896958896958Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious DiseasesLu Yang0Lin Tang1Ming Zhang2Chaoyong Liu3Chaoyong Liu4College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, ChinaDepartment of Pathology, Peking University International Hospital, Beijing, ChinaCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, ChinaVaccines can prevent many millions of illnesses against infectious diseases and save numerous lives every year. However, traditional vaccines such as inactivated viral and live attenuated vaccines cannot adapt to emerging pandemics due to their time-consuming development. With the global outbreak of the COVID-19 epidemic, the virus continues to evolve and mutate, producing mutants with enhanced transmissibility and virulence; the rapid development of vaccines against such emerging global pandemics becomes more and more critical. In recent years, mRNA vaccines have been of significant interest in combating emerging infectious diseases due to their rapid development and large-scale production advantages. However, their development still suffers from many hurdles such as their safety, cellular delivery, uptake, and response to their manufacturing, logistics, and storage. More efforts are still required to optimize the molecular designs of mRNA molecules with increased protein expression and enhanced structural stability. In addition, a variety of delivery systems are also needed to achieve effective delivery of vaccines. In this review, we highlight the advances in mRNA vaccines against various infectious diseases and discuss the molecular design principles and delivery systems of associated mRNA vaccines. The current state of the clinical application of mRNA vaccine pipelines against various infectious diseases and the challenge, safety, and protective effect of associated vaccines are also discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2022.896958/fullmRNA vaccineinfectious diseasesCOVID-19mRNA structure designmRNA delivery |
| spellingShingle | Lu Yang Lin Tang Ming Zhang Chaoyong Liu Chaoyong Liu Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases Frontiers in Immunology mRNA vaccine infectious diseases COVID-19 mRNA structure design mRNA delivery |
| title | Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases |
| title_full | Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases |
| title_fullStr | Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases |
| title_full_unstemmed | Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases |
| title_short | Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases |
| title_sort | recent advances in the molecular design and delivery technology of mrna for vaccination against infectious diseases |
| topic | mRNA vaccine infectious diseases COVID-19 mRNA structure design mRNA delivery |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896958/full |
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