Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease.
Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains amb...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0264333 |
| _version_ | 1818445883477327872 |
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| author | Kati Valkonen Jyrki P Mäkelä Katja Airaksinen Jussi Nurminen Riku Kivisaari Hanna Renvall Eero Pekkonen |
| author_facet | Kati Valkonen Jyrki P Mäkelä Katja Airaksinen Jussi Nurminen Riku Kivisaari Hanna Renvall Eero Pekkonen |
| author_sort | Kati Valkonen |
| collection | DOAJ |
| description | Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS. |
| first_indexed | 2024-12-14T19:38:54Z |
| format | Article |
| id | doaj.art-e25d5bcfcf0e4cf8a6f9baa3a5a66177 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T19:38:54Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e25d5bcfcf0e4cf8a6f9baa3a5a661772022-12-21T22:49:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026433310.1371/journal.pone.0264333Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease.Kati ValkonenJyrki P MäkeläKatja AiraksinenJussi NurminenRiku KivisaariHanna RenvallEero PekkonenDeep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.https://doi.org/10.1371/journal.pone.0264333 |
| spellingShingle | Kati Valkonen Jyrki P Mäkelä Katja Airaksinen Jussi Nurminen Riku Kivisaari Hanna Renvall Eero Pekkonen Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. PLoS ONE |
| title | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. |
| title_full | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. |
| title_fullStr | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. |
| title_full_unstemmed | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. |
| title_short | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease. |
| title_sort | deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced parkinson s disease |
| url | https://doi.org/10.1371/journal.pone.0264333 |
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