Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

Abstract Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not suffici...

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Bibliographic Details
Main Authors: Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch, Fumito Ichinose
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
Hypoxic pulmonary vasoconstriction
Endotoxemia
Arginase
Nitric oxide synthase
Online Access:http://link.springer.com/article/10.1186/s12931-019-1062-6

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