Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences
Malaria caused by Plasmodium vivax is being diagnosed with increasing frequency in Africa. Some southern countries where it has been detected are Angola, Botswana, Mozambique, Namibia, Zambia and Zimbabwe. Knowing the parasite origin of P. vivax infection recurrences (which can be reinfections, recr...
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| Format: | Article |
| Language: | English |
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AOSIS
2022-03-01
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| Series: | Southern African Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://sajid.co.za/index.php/sajid/article/view/369 |
| _version_ | 1818351733549563904 |
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| author | Miles B. Markus |
| author_facet | Miles B. Markus |
| author_sort | Miles B. Markus |
| collection | DOAJ |
| description | Malaria caused by Plasmodium vivax is being diagnosed with increasing frequency in Africa. Some southern countries where it has been detected are Angola, Botswana, Mozambique, Namibia, Zambia and Zimbabwe. Knowing the parasite origin of P. vivax infection recurrences (which can be reinfections, recrudescences or relapses) is important epidemiologically for malaria elimination in Africa. Although hypnozoites will no doubt be a source, we should try to determine how frequently the origin of non-reinfection recurrences of P. vivax malaria involving closely related parasites may be non-circulating merozoites rather than hypnozoites. |
| first_indexed | 2024-12-13T18:42:26Z |
| format | Article |
| id | doaj.art-e2615d6da41e4a019e6ea98ac0bf7600 |
| institution | Directory Open Access Journal |
| issn | 2312-0053 2313-1810 |
| language | English |
| last_indexed | 2024-12-13T18:42:26Z |
| publishDate | 2022-03-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of Infectious Diseases |
| spelling | doaj.art-e2615d6da41e4a019e6ea98ac0bf76002022-12-21T23:35:10ZengAOSISSouthern African Journal of Infectious Diseases2312-00532313-18102022-03-01371e1e210.4102/sajid.v37i1.369224Theoretical origin of genetically homologous Plasmodium vivax malarial recurrencesMiles B. Markus0Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and, School of Animal, Plant and Environmental Sciences, Faculty of Science, University of the Witwatersrand, JohannesburgMalaria caused by Plasmodium vivax is being diagnosed with increasing frequency in Africa. Some southern countries where it has been detected are Angola, Botswana, Mozambique, Namibia, Zambia and Zimbabwe. Knowing the parasite origin of P. vivax infection recurrences (which can be reinfections, recrudescences or relapses) is important epidemiologically for malaria elimination in Africa. Although hypnozoites will no doubt be a source, we should try to determine how frequently the origin of non-reinfection recurrences of P. vivax malaria involving closely related parasites may be non-circulating merozoites rather than hypnozoites.https://sajid.co.za/index.php/sajid/article/view/369epidemiologygenotypinghypnozoiteidentity by descentmeiotic siblingplasmodium vivaxprimaquinerelapsesingle-cell sequencingwhole-genome sequencing |
| spellingShingle | Miles B. Markus Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences Southern African Journal of Infectious Diseases epidemiology genotyping hypnozoite identity by descent meiotic sibling plasmodium vivax primaquine relapse single-cell sequencing whole-genome sequencing |
| title | Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences |
| title_full | Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences |
| title_fullStr | Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences |
| title_full_unstemmed | Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences |
| title_short | Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences |
| title_sort | theoretical origin of genetically homologous plasmodium vivax malarial recurrences |
| topic | epidemiology genotyping hypnozoite identity by descent meiotic sibling plasmodium vivax primaquine relapse single-cell sequencing whole-genome sequencing |
| url | https://sajid.co.za/index.php/sajid/article/view/369 |
| work_keys_str_mv | AT milesbmarkus theoreticaloriginofgeneticallyhomologousplasmodiumvivaxmalarialrecurrences |