Association between FY*02N.01 and the severity of COVID-19: initial observations
ABSTRACT: Introduction: The pro-inflammatory immune response underlies severe cases of COVID-19. Antigens of the Duffy blood group systems are receptors for pro-inflammation chemokines. The ACKR1 c.-67T>C gene variation silences the expression of Duffy antigens on erythrocytes and individuals pr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-04-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137922000098 |
| _version_ | 1811233684492124160 |
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| author | Marina C.A.V. Conrado Marcia R. Dezan Valéria Brito Oliveira Karen Chinoca Ziza Tila Fanciscani Vanderson Rocha Alfredo Mendrone-Júnior Carla Luana Dinardo |
| author_facet | Marina C.A.V. Conrado Marcia R. Dezan Valéria Brito Oliveira Karen Chinoca Ziza Tila Fanciscani Vanderson Rocha Alfredo Mendrone-Júnior Carla Luana Dinardo |
| author_sort | Marina C.A.V. Conrado |
| collection | DOAJ |
| description | ABSTRACT: Introduction: The pro-inflammatory immune response underlies severe cases of COVID-19. Antigens of the Duffy blood group systems are receptors for pro-inflammation chemokines. The ACKR1 c.-67T>C gene variation silences the expression of Duffy antigens on erythrocytes and individuals presenting this variant in homozygosity have impaired inflammatory response control. Our aim was to evaluate the association between the ACKR1 c.-67T>C and the severity of COVID-19. Methods: This was a retrospective single-center case-control study, enrolling 164 participants who were divided into four groups: 1) Death: COVID-19 patients who died during hospitalization; 2) Hospital Discharge: COVID-19 patients who were discharged for home after hospitalizations; 3) Convalescent Plasma Donors: COVID-19 patients who were not hospitalized, and; 4) Controls: patients with diagnosis other than COVID-19. Patients were genotyped for the ACKR1 c.-67T>C (FY*02 N.01 allele) and the frequency of individuals presenting the altered allele was compared between the groups. Results: The groups significantly differed in terms of the percentage of patients presenting at least one FY*02N.01 allele: 36.8% (Death group), 37% (Hospital Discharge group), 16.1% (Convalescent Plasma group) and 16.2% (Control group) (p = 0.027). The self-declared race (p < 0.001) and the occurrence of in hospital death (p = 0.058) were independently associated with the presence of the FY*02N.01 allele. Hypertension (p < 0.001), age (p < 0.001) and the presence of at least one FY*02N.01 allele (p = 0.009) were independently associated with the need for hospitalization. Conclusion: There is a suggestive association between the presence of the FY*02N.01 and the severity of COVID-19. This may be a mechanism underlying the worse prognosis for Afro-descendants infected with SARS-CoV-2. |
| first_indexed | 2024-04-12T11:24:47Z |
| format | Article |
| id | doaj.art-e261c48edb43447d8fe82c19a737130a |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-04-12T11:24:47Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-e261c48edb43447d8fe82c19a737130a2022-12-22T03:35:16ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-04-01442213217Association between FY*02N.01 and the severity of COVID-19: initial observationsMarina C.A.V. Conrado0Marcia R. Dezan1Valéria Brito Oliveira2Karen Chinoca Ziza3Tila Fanciscani4Vanderson Rocha5Alfredo Mendrone-Júnior6Carla Luana Dinardo7Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, BrazilFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, BrazilFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, BrazilFaculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, BrazilFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, BrazilFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil; Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Churchill Hospital, NHS BT, Oxford University, Oxford, United KingdomFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, BrazilFundação Pró-Sangue Hemocentro de São Paulo, São Paulo, SP, Brazil; Instituto de Medicina Tropical de São Paulo da Universidade de São Paulo (IMTSP USP), São Paulo, SP, Brazil; Corresponding author at: Enéas de Carvalho Aguiar, 155, 1st floor, room 114, Pinheiros, CEP: 05401000.ABSTRACT: Introduction: The pro-inflammatory immune response underlies severe cases of COVID-19. Antigens of the Duffy blood group systems are receptors for pro-inflammation chemokines. The ACKR1 c.-67T>C gene variation silences the expression of Duffy antigens on erythrocytes and individuals presenting this variant in homozygosity have impaired inflammatory response control. Our aim was to evaluate the association between the ACKR1 c.-67T>C and the severity of COVID-19. Methods: This was a retrospective single-center case-control study, enrolling 164 participants who were divided into four groups: 1) Death: COVID-19 patients who died during hospitalization; 2) Hospital Discharge: COVID-19 patients who were discharged for home after hospitalizations; 3) Convalescent Plasma Donors: COVID-19 patients who were not hospitalized, and; 4) Controls: patients with diagnosis other than COVID-19. Patients were genotyped for the ACKR1 c.-67T>C (FY*02 N.01 allele) and the frequency of individuals presenting the altered allele was compared between the groups. Results: The groups significantly differed in terms of the percentage of patients presenting at least one FY*02N.01 allele: 36.8% (Death group), 37% (Hospital Discharge group), 16.1% (Convalescent Plasma group) and 16.2% (Control group) (p = 0.027). The self-declared race (p < 0.001) and the occurrence of in hospital death (p = 0.058) were independently associated with the presence of the FY*02N.01 allele. Hypertension (p < 0.001), age (p < 0.001) and the presence of at least one FY*02N.01 allele (p = 0.009) were independently associated with the need for hospitalization. Conclusion: There is a suggestive association between the presence of the FY*02N.01 and the severity of COVID-19. This may be a mechanism underlying the worse prognosis for Afro-descendants infected with SARS-CoV-2.http://www.sciencedirect.com/science/article/pii/S2531137922000098COVID-19DuffyDARC |
| spellingShingle | Marina C.A.V. Conrado Marcia R. Dezan Valéria Brito Oliveira Karen Chinoca Ziza Tila Fanciscani Vanderson Rocha Alfredo Mendrone-Júnior Carla Luana Dinardo Association between FY*02N.01 and the severity of COVID-19: initial observations Hematology, Transfusion and Cell Therapy COVID-19 Duffy DARC |
| title | Association between FY*02N.01 and the severity of COVID-19: initial observations |
| title_full | Association between FY*02N.01 and the severity of COVID-19: initial observations |
| title_fullStr | Association between FY*02N.01 and the severity of COVID-19: initial observations |
| title_full_unstemmed | Association between FY*02N.01 and the severity of COVID-19: initial observations |
| title_short | Association between FY*02N.01 and the severity of COVID-19: initial observations |
| title_sort | association between fy 02n 01 and the severity of covid 19 initial observations |
| topic | COVID-19 Duffy DARC |
| url | http://www.sciencedirect.com/science/article/pii/S2531137922000098 |
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