The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings
Abstract Objectives Individuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3669-y |
| _version_ | 1818492092118204416 |
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| author | Mulyadi Sunnati Mulkan Azhary Faisal Yunus Fariz Nurwidya |
| author_facet | Mulyadi Sunnati Mulkan Azhary Faisal Yunus Fariz Nurwidya |
| author_sort | Mulyadi |
| collection | DOAJ |
| description | Abstract Objectives Individuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue degradation of lung extracellular matrix among COPD individuals. The purpose of the present study was to correlate age and/or BMI with salivary levels of MMP-3 and TIMP-1 among Indonesian subjects with COPD. Results Thirty COPD patients were recruited to undergo thorough physical assessment and saliva collection for evaluating TIMP-1 and MMP-3 levels using commercially available kits enzyme-linked immunosorbent assay method. The mean (standard deviation) participant age and BMI were 60.5 (8.13) years, and 23.1 (4.75) kg/m2, respectively. Furthermore, the mean (standard deviation) of TIMP-1 and MMP3 levels were 23.99 (6.85) ng/mL and 1.81 (1.167) μM, respectively. Age was negatively correlated with MMP-3 (P < 0.05), but not with TIMP-1 levels. Age and BMI were not correlated with TIMP-1 level (P > 0.05). Collectively, this study demonstrated that age has a negative correlation with the protease marker (i.e. MMP-3), but not the anti-protease marker (TIMP-1). BMI was not correlated with either protease/anti-protease marker among Indonesian subjects with COPD. |
| first_indexed | 2024-12-10T17:38:53Z |
| format | Article |
| id | doaj.art-e261d373efec4644bede9eafd235ed9e |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-10T17:38:53Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-e261d373efec4644bede9eafd235ed9e2022-12-22T01:39:26ZengBMCBMC Research Notes1756-05002018-08-011111410.1186/s13104-018-3669-yThe correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findingsMulyadi0Sunnati1Mulkan Azhary2Faisal Yunus3Fariz Nurwidya4Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah KualaDepartment of Periodontology, Faculty of Dentistry, Universitas Syiah KualaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah KualaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan HospitalDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan HospitalAbstract Objectives Individuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue degradation of lung extracellular matrix among COPD individuals. The purpose of the present study was to correlate age and/or BMI with salivary levels of MMP-3 and TIMP-1 among Indonesian subjects with COPD. Results Thirty COPD patients were recruited to undergo thorough physical assessment and saliva collection for evaluating TIMP-1 and MMP-3 levels using commercially available kits enzyme-linked immunosorbent assay method. The mean (standard deviation) participant age and BMI were 60.5 (8.13) years, and 23.1 (4.75) kg/m2, respectively. Furthermore, the mean (standard deviation) of TIMP-1 and MMP3 levels were 23.99 (6.85) ng/mL and 1.81 (1.167) μM, respectively. Age was negatively correlated with MMP-3 (P < 0.05), but not with TIMP-1 levels. Age and BMI were not correlated with TIMP-1 level (P > 0.05). Collectively, this study demonstrated that age has a negative correlation with the protease marker (i.e. MMP-3), but not the anti-protease marker (TIMP-1). BMI was not correlated with either protease/anti-protease marker among Indonesian subjects with COPD.http://link.springer.com/article/10.1186/s13104-018-3669-yAgeBMISalivary MMP-3Salivary TIMP-1 |
| spellingShingle | Mulyadi Sunnati Mulkan Azhary Faisal Yunus Fariz Nurwidya The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings BMC Research Notes Age BMI Salivary MMP-3 Salivary TIMP-1 |
| title | The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings |
| title_full | The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings |
| title_fullStr | The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings |
| title_full_unstemmed | The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings |
| title_short | The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings |
| title_sort | correlation of age and body mass index with the level of both protease mmp3 and anti protease timp 1 among indonesian patients with chronic obstructive pulmonary disease a preliminary findings |
| topic | Age BMI Salivary MMP-3 Salivary TIMP-1 |
| url | http://link.springer.com/article/10.1186/s13104-018-3669-y |
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