Development and Assessment of a Novel Whole-Gene-Based Targeted Next-Generation Sequencing Assay for Detecting the Susceptibility of Mycobacterium tuberculosis to 14 Drugs

Development and Assessment of a Novel Whole-Gene-Based Targeted Next-Generation Sequencing Assay for Detecting the Susceptibility of Mycobacterium tuberculosis to 14 Drugs

ABSTRACT Targeted next-generation sequencing (tNGS) has emerged as an alternative method for detecting drug-resistant tuberculosis (DR-TB). To provide comprehensive drug susceptibility information and to address mutations missed by available commercial molecular diagnostics, we developed and evaluat...

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Bibliographic Details
Main Authors: Sheng-Han Wu, Yu-Xin Xiao, Hseuh-Chien Hsiao, Ruwen Jou
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
whole-genome sequencing
targeted NGS
drug susceptibility
heteroresistance
tuberculosis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02605-22

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