COVID-19 in renal-transplanted recipients: a narrative review
COVID-19 is an emerging disease mainly associated with Severe Acute Respiratory Syndrome (SARS). This disease causes a cytokine storm release in response to viral infection, and can lead to several systemic complications. Acute kidney injury (AKI) is one of these complications and renal replacement...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Transplante de Órgãos
2021-09-01
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| Series: | Brazilian Journal of Transplantation |
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| Online Access: | https://bjt.emnuvens.com.br/revista/article/view/19 |
| _version_ | 1811297040254107648 |
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| author | Suellen Rodrigues Martins Lorraine Vieira Alves Marta Lamounier Moura Vargas Corgozinho Jenner Karlisson Pimenta dos Reis Bruno Eduardo Fernandes Mota Kátia de Paula Farah Karina Braga Gomes Luci Maria Santana Dusse Patrícia Nessralla Alpoim Ana Paula Lucas Mota |
| author_facet | Suellen Rodrigues Martins Lorraine Vieira Alves Marta Lamounier Moura Vargas Corgozinho Jenner Karlisson Pimenta dos Reis Bruno Eduardo Fernandes Mota Kátia de Paula Farah Karina Braga Gomes Luci Maria Santana Dusse Patrícia Nessralla Alpoim Ana Paula Lucas Mota |
| author_sort | Suellen Rodrigues Martins |
| collection | DOAJ |
| description |
COVID-19 is an emerging disease mainly associated with Severe Acute Respiratory Syndrome (SARS). This disease causes a cytokine storm release in response to viral infection, and can lead to several systemic complications. Acute kidney injury (AKI) is one of these complications and renal replacement therapy may be necessary for the infected patient. In this context, renal-transplanted recipients (RTR) and patients with chronic kidney diseases are in the risk groups for COVID-19 due to their increased inflammatory state and endothelial dysfunction. Furthermore, maintenance immunosuppressive therapy in RTR can also be another complicating factor, since it influences the response from the immune system against pathogens, including SARS-CoV-2. However, it is believed that the worst outcomes of COVID-19 are mainly caused by an exaggerated inflammatory response than to the direct virus action; therefore, in a hyper-inflammatory state, immunosuppression therapy could be beneficial. This narrative review aims to present the main clinical and laboratory findings of 22 studies involving RTR affected by COVID-19. This review can contribute to the management of COVID-19 and its consequences in this risk group.
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| first_indexed | 2024-04-13T05:58:10Z |
| format | Article |
| id | doaj.art-e264736adfdd486ea0d78e2efb0dc1bf |
| institution | Directory Open Access Journal |
| issn | 2764-1589 |
| language | English |
| last_indexed | 2024-04-13T05:58:10Z |
| publishDate | 2021-09-01 |
| publisher | Associação Brasileira de Transplante de Órgãos |
| record_format | Article |
| series | Brazilian Journal of Transplantation |
| spelling | doaj.art-e264736adfdd486ea0d78e2efb0dc1bf2022-12-22T02:59:33ZengAssociação Brasileira de Transplante de ÓrgãosBrazilian Journal of Transplantation2764-15892021-09-0124210.53855/bjt.v24i2.19COVID-19 in renal-transplanted recipients: a narrative reviewSuellen Rodrigues Martins0Lorraine Vieira Alves1Marta Lamounier Moura Vargas Corgozinho2Jenner Karlisson Pimenta dos Reis3Bruno Eduardo Fernandes Mota4Kátia de Paula Farah5Karina Braga Gomes6Luci Maria Santana Dusse7Patrícia Nessralla Alpoim8Ana Paula Lucas Mota9Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Medicina Veterinária - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Medicina - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil. COVID-19 is an emerging disease mainly associated with Severe Acute Respiratory Syndrome (SARS). This disease causes a cytokine storm release in response to viral infection, and can lead to several systemic complications. Acute kidney injury (AKI) is one of these complications and renal replacement therapy may be necessary for the infected patient. In this context, renal-transplanted recipients (RTR) and patients with chronic kidney diseases are in the risk groups for COVID-19 due to their increased inflammatory state and endothelial dysfunction. Furthermore, maintenance immunosuppressive therapy in RTR can also be another complicating factor, since it influences the response from the immune system against pathogens, including SARS-CoV-2. However, it is believed that the worst outcomes of COVID-19 are mainly caused by an exaggerated inflammatory response than to the direct virus action; therefore, in a hyper-inflammatory state, immunosuppression therapy could be beneficial. This narrative review aims to present the main clinical and laboratory findings of 22 studies involving RTR affected by COVID-19. This review can contribute to the management of COVID-19 and its consequences in this risk group. https://bjt.emnuvens.com.br/revista/article/view/19Communicable DiseaseCoronavirus InfectionsRenal InsufficiencyKidney Transplantation |
| spellingShingle | Suellen Rodrigues Martins Lorraine Vieira Alves Marta Lamounier Moura Vargas Corgozinho Jenner Karlisson Pimenta dos Reis Bruno Eduardo Fernandes Mota Kátia de Paula Farah Karina Braga Gomes Luci Maria Santana Dusse Patrícia Nessralla Alpoim Ana Paula Lucas Mota COVID-19 in renal-transplanted recipients: a narrative review Brazilian Journal of Transplantation Communicable Disease Coronavirus Infections Renal Insufficiency Kidney Transplantation |
| title | COVID-19 in renal-transplanted recipients: a narrative review |
| title_full | COVID-19 in renal-transplanted recipients: a narrative review |
| title_fullStr | COVID-19 in renal-transplanted recipients: a narrative review |
| title_full_unstemmed | COVID-19 in renal-transplanted recipients: a narrative review |
| title_short | COVID-19 in renal-transplanted recipients: a narrative review |
| title_sort | covid 19 in renal transplanted recipients a narrative review |
| topic | Communicable Disease Coronavirus Infections Renal Insufficiency Kidney Transplantation |
| url | https://bjt.emnuvens.com.br/revista/article/view/19 |
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